iPTMnet Report for P17752 (TPH1)
Protein Information
UniProt AC / UniProt ID | P17752 / TPH1_HUMAN |
Protein Name | Tryptophan 5-hydroxylase 1 |
Gene Name | Name: TPH1 Synonyms:TPH,TPRH,TRPH; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P17752 |
PRO Name | tryptophan 5-hydroxylase 1 (human) |
Definition | A tryptophan 5-hydroxylase 1 that is encoded in the genome of human. |
Short Label | hTPH1 |
Category | organism-gene |
P17752 (TPH1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K33 | Acetylation | score1 | PhosphoSitePlus | |||
S58 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 9109552 | ||
T225 | Phosphorylation | score1 | PhosphoSitePlus | |||
S228 | Phosphorylation | score1 | PhosphoSitePlus | |||
S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
T315 | O-Glycosylation | score1 | GlyGen | 35254053 | ||
Y373 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y401 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y404 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S260 | L260 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y373 | H373 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
Y401 | C401 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] |