iPTMnet Report for P17752 (TPH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17752 / TPH1_HUMAN
Protein Name Tryptophan 5-hydroxylase 1
Gene Name Name: TPH1
Synonyms:TPH,TPRH,TRPH;
Organism Homo sapiens (Human)

PRO ID PR:P17752
DAG View
PRO Name tryptophan 5-hydroxylase 1 (human)
Definition A tryptophan 5-hydroxylase 1 that is encoded in the genome of human.
Short Label hTPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17752 (TPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K33 Acetylation PhosphoSitePlus
S58 Phosphorylation phospho.ELM   PhosphoSitePlus 9109552
T225 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
T315 O-Glycosylation GlyGen 35254053
Y373 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation P17612 (PRKACA) HPRD 9109552


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S260 L260 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y373 H373 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y401 C401 Biomuta DOID:10283 / prostate cancer [ cosmic ]