iPTMnet Report for P17655 (CAPN2)
Protein Information
UniProt AC / UniProt ID | P17655 / CAN2_HUMAN |
Protein Name | Calpain-2 catalytic subunit precursor |
Gene Name | Name: CAPN2 Synonyms:CANPL2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P17655 |
PRO Name | calpain-2 catalytic subunit (human) |
Definition | A calpain-2 catalytic subunit that is encoded in the genome of human. |
Short Label | hCAPN2 |
Category | organism-gene |
P17655 (CAPN2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 22814378 | ||
K7 | Acetylation | score1 | PhosphoSitePlus | |||
S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
R23 | Methylation | score1 | PhosphoSitePlus | |||
K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y32 | Phosphorylation | score1 | PhosphoSitePlus | |||
S50 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 14993287, 26248159 | ||
S50 | Phosphorylation | P27361 (MAPK3) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor | 14993287 | |
S50 | Phosphorylation | P28482 (MAPK1) | score3 | phospho.ELM PhosphoSitePlus Signor | 14993287 | |
K61 | Acetylation | score1 | PhosphoSitePlus | |||
K61 | Ubiquitination | score1 | PhosphoSitePlus | |||
S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
C82 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794 | ||
K219 | Ubiquitination | score1 | PhosphoSitePlus | |||
K230 | Ubiquitination | score1 | PhosphoSitePlus | |||
K234 | Ubiquitination | score1 | PhosphoSitePlus | |||
K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y353 | Phosphorylation | score1 | PhosphoSitePlus | |||
K354 | Acetylation | score1 | PhosphoSitePlus | |||
K355 | Acetylation | score1 | PhosphoSitePlus | |||
K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
S369 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P | 11909964, 28235949, 26248159 | ||
S369 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt PhosphoSitePlus | 11909964 | |
T370 | Phosphorylation | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor | 11909964 | ||
T370 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt PhosphoSitePlus Signor | 11909964 | |
K390 | Sumoylation | score1 | PhosphoSitePlus | |||
S403 | Phosphorylation | score1 | PhosphoSitePlus | |||
K414 | Ubiquitination | score1 | PhosphoSitePlus | |||
S462 | Phosphorylation | score1 | PhosphoSitePlus | |||
T464 | Phosphorylation | score1 | PhosphoSitePlus | |||
K476 | Ubiquitination | score1 | PhosphoSitePlus | |||
K568 | Ubiquitination | score1 | PhosphoSitePlus | |||
S569 | Phosphorylation | score1 | PhosphoSitePlus | |||
C577 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794 | ||
S586 | Phosphorylation | score1 | PhosphoSitePlus | |||
S589 | Phosphorylation | score1 | PhosphoSitePlus | |||
K591 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y611 | Phosphorylation | score1 | PhosphoSitePlus | |||
T621 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y625 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 35697802 | ||
K629 | Ubiquitination | score1 | PhosphoSitePlus | |||
K674 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S20 | P20 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
S68 | G68 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ] | |
S369 | F369 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K390 | N390 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K476 | R476 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
K568 | Q568 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
S569 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S586 | L586 | Biomuta | DOID:363 / uterine cancer [ icgc ] |