Protein Information

Cytoscape View


UniProt AC / UniProt ID P17655 / CAN2_HUMAN
Protein Name Calpain-2 catalytic subunit precursor
Gene Name Name: CAPN2
Synonyms:CANPL2;
Organism Homo sapiens (Human)

PRO ID PR:P17655
DAG View
PRO Name calpain-2 catalytic subunit (human)
Definition A calpain-2 catalytic subunit that is encoded in the genome of human.
Short Label hCAPN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17655 (CAPN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K7 Acetylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
R23 Methylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
S50 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14993287, 26248159
K61 Acetylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
C82 S-Nitrosylation dbSNO 2212679, 22126794
K219 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
K354 Acetylation PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S369 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 28235949, 11909964, 26248159
T370 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11909964
K390 Sumoylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
C577 S-Nitrosylation dbSNO 2212679, 22126794
S586 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
Y625 Phosphorylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 P20 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
R23 M23 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S68 G68 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S369 F369 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K390 N390 Biomuta DOID:363 / uterine cancer [ tcga ]
K568 Q568 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S586 L586 Biomuta DOID:363 / uterine cancer [ tcga ]