iPTMnet Report for P17655 (CAPN2)
Protein Information
| UniProt AC / UniProt ID | P17655 / CAN2_HUMAN |
| Protein Name | Calpain-2 catalytic subunit precursor |
| Gene Name | Name: CAPN2 Synonyms:CANPL2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P17655 |
| PRO Name | calpain-2 catalytic subunit (human) |
| Definition | A calpain-2 catalytic subunit that is encoded in the genome of human. |
| Short Label | hCAPN2 |
| Category | organism-gene |
P17655 (CAPN2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 22814378 | ||
| K7 | Acetylation | score1 | PhosphoSitePlus | |||
| S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R23 | Methylation | score1 | PhosphoSitePlus | |||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y32 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S50 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 14993287, 26248159 | |
| K61 | Acetylation | score1 | PhosphoSitePlus | |||
| K61 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C82 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794 | ||
| K219 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K230 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K234 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y353 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K354 | Acetylation | score1 | PhosphoSitePlus | |||
| K355 | Acetylation | score1 | PhosphoSitePlus | |||
| K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S369 | Phosphorylation | P17612 (PRKACA) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P | 11909964, 28235949, 26248159 | |
| T370 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor | 11909964 | |
| K390 | Sumoylation | score1 | PhosphoSitePlus | |||
| S403 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K414 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S462 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T464 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K476 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K568 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S569 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C577 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794 | ||
| S586 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S589 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K591 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y611 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T621 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y625 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 35697802 | ||
| K629 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K674 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S20 | P20 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
| S68 | G68 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ] | |
| S369 | F369 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K390 | N390 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K476 | R476 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
| K568 | Q568 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
| S569 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S586 | L586 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
DAG View