iPTMnet Report for P17096 (HMGA1)
Protein Information
UniProt AC / UniProt ID | P17096 / HMGA1_HUMAN |
Protein Name | High mobility group protein HMG-I/HMG-Y |
Gene Name | Name: HMGA1 Synonyms:HMGIY; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P17096 |
PRO Name | high mobility group protein HMG-I/HMG-Y (human) |
Definition | A high mobility group protein HMG-I/HMG-Y that is encoded in the genome of human. |
Short Label | hHMGA1 |
Category | organism-gene |
P17096 (HMGA1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
K7 | Acetylation | score1 | PhosphoSitePlus | |||
K7 | Methylation | score1 | PhosphoSitePlus | |||
K7 | Ubiquitination | score1 | PhosphoSitePlus | |||
S8 | Phosphorylation | score1 | PhosphoSitePlus | |||
S9 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
K15 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K15 | Methylation | score1 | PhosphoSitePlus | |||
K15 | Ubiquitination | score1 | PhosphoSitePlus | |||
K18 | Acetylation | score1 | PhosphoSitePlus | |||
T21 | Phosphorylation | score1 | PhosphoSitePlus | |||
K23 | Acetylation | score1 | PhosphoSitePlus | |||
K23 | Methylation | score1 | PhosphoSitePlus | |||
R24 | Methylation | score1 | PhosphoSitePlus | |||
R26 | Methylation | score4 | PhosphoSitePlus UniProt | 12653562, 15835918 | ||
K31 | Acetylation | score1 | PhosphoSitePlus | |||
K31 | Methylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
S36 | Phosphorylation | P06493 (CDK1) , Q9H2X6 (HIPK2) , P24941 (CDK2) | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 23186163, 17081983, ... | |
T39 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 24275569 | ||
V42 | Phosphorylation | score3 | UniProt | 17960875, 21406692, 17924679 | ||
S44 | Phosphorylation | Q05655 (PRKCD) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 17525332, 23186163, 18669648, ... | |
K46 | Acetylation | score1 | PhosphoSitePlus | |||
K46 | Methylation | score1 | PhosphoSitePlus | |||
K46 | Ubiquitination | score1 | PhosphoSitePlus | |||
S49 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 24275569 | ||
T53 | Phosphorylation | P06493 (CDK1) , Q9H2X6 (HIPK2) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 23186163, 11593421, ... | |
K55 | Acetylation | score1 | PhosphoSitePlus | |||
K55 | Methylation | score1 | PhosphoSitePlus | |||
K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
R58 | Methylation | score3 | PhosphoSitePlus UniProt | 16159886 | ||
R60 | Methylation | score3 | PhosphoSitePlus UniProt | 16159886 | ||
K62 | Acetylation | score1 | PhosphoSitePlus | |||
K62 | Methylation | score1 | PhosphoSitePlus | |||
S64 | Phosphorylation | Q05655 (PRKCD) | score4 | PhosphoSitePlus RLIMS-P Signor | 10617144, 31340016 | |
K65 | Acetylation | score1 | PhosphoSitePlus | |||
K65 | Methylation | score1 | PhosphoSitePlus | |||
K65 | Sumoylation | score1 | PhosphoSitePlus | |||
K67 | Acetylation | score1 | PhosphoSitePlus | |||
K67 | Methylation | score1 | PhosphoSitePlus | |||
K67 | Phosphorylation | score2 | UniProt | 17960875 | ||
K71 | Acetylation | score1 | PhosphoSitePlus | |||
K71 | Methylation | score1 | PhosphoSitePlus | |||
T72 | Phosphorylation | score1 | PhosphoSitePlus | |||
R73 | Methylation | score1 | PhosphoSitePlus | |||
K74 | Acetylation | score1 | PhosphoSitePlus | |||
K74 | Methylation | score1 | PhosphoSitePlus | |||
T75 | Phosphorylation | score1 | PhosphoSitePlus | |||
T76 | Phosphorylation | score1 | PhosphoSitePlus | |||
T77 | Phosphorylation | score1 | PhosphoSitePlus | |||
T78 | Phosphorylation | P06493 (CDK1) , Q9H2X6 (HIPK2) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 11593421, 31340016, 15302935, ... | |
R81 | Methylation | score1 | PhosphoSitePlus | |||
K82 | Acetylation | score1 | PhosphoSitePlus | |||
R84 | Methylation | score1 | PhosphoSitePlus | |||
R86 | Methylation | score1 | PhosphoSitePlus | |||
K88 | Acetylation | score1 | PhosphoSitePlus | |||
S99 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 17525332, 16083285, 15835918, ... | ||
S102 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 17525332, 16083285, 15835918, ... | ||
S103 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 17525332, 16083285, 15835918, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S36 | Phosphorylation | score0 | HPRD | 19413330, 19664995, 19651622, ... | ||
T39 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 17081983, ... | ||
S44 | Phosphorylation | score0 | HPRD | 17525332, 19664995, 18452278, ... | ||
S49 | Phosphorylation | score0 | HPRD | 14729942, 19651622, 18669648, ... | ||
T53 | Phosphorylation | P06493 (CDK1) | score2 | HPRD | 19413330, 19664995, 1939057, ... | |
T78 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 1939057 | |
S99 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | score2 | HPRD | 18452278, 19651622, 2806554, ... | |
S102 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | score2 | HPRD | 19413330, 18491316, 18452278, ... | |
S103 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | score2 | HPRD | 19413330, 18491316, 18452278, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K15 | Acetylation | score1 | PhosphoSitePlus | |||
K15 | Methylation | score1 | PhosphoSitePlus | |||
K18 | Acetylation | score1 | PhosphoSitePlus | |||
T21 | Phosphorylation | score1 | PhosphoSitePlus | |||
K23 | Acetylation | score1 | PhosphoSitePlus | |||
R24 | Methylation | score1 | PhosphoSitePlus | |||
R26 | Methylation | score1 | PhosphoSitePlus | |||
K31 | Acetylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
K35 | Acetylation | score1 | PhosphoSitePlus | |||
K35 | Ubiquitination | score1 | PhosphoSitePlus | |||
S38 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 14729942, 18669648, 20068231, ... | ||
T42 | Phosphorylation | Q9H2X6 (HIPK2) , P06493 (CDK1) | score4 | HPRD PhosphoSitePlus | 19413330, 17960875, 18234856, ... | |
K44 | Acetylation | score1 | PhosphoSitePlus | |||
R45 | Methylation | score1 | PhosphoSitePlus | |||
R47 | Methylation | score1 | PhosphoSitePlus | |||
R49 | Methylation | score1 | PhosphoSitePlus | |||
S53 | Phosphorylation | score1 | PhosphoSitePlus | |||
K54 | Acetylation | score1 | PhosphoSitePlus | |||
K56 | Acetylation | score1 | PhosphoSitePlus | |||
K60 | Acetylation | score1 | PhosphoSitePlus | |||
K63 | Acetylation | score1 | PhosphoSitePlus | |||
T67 | Phosphorylation | Q9H2X6 (HIPK2) , P06493 (CDK1) | score4 | HPRD PhosphoSitePlus | 17960875, 1939057 | |
K71 | Acetylation | score1 | PhosphoSitePlus | |||
R73 | Methylation | score1 | PhosphoSitePlus | |||
K81 | Methylation | score1 | PhosphoSitePlus | |||
S88 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | score4 | HPRD PhosphoSitePlus | 18452278, 19651622, 2806554, ... | |
S91 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | score4 | HPRD PhosphoSitePlus | 19413330, 18491316, 18452278, ... | |
S92 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | score4 | HPRD PhosphoSitePlus | 19413330, 18491316, 18452278, ... |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:Q92793-1 (hCREBBP/iso:1) | Interaction | PR:P17096 (hHMGA1) | PRO | 10428834 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T21 | N21 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
R24 | W24 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K44 | N44 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
R47 | W47 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K55 | N55 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
R58 | W58 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
T75 | I75 | Biomuta | [ cosmic ] | |
K88 | N88 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |