iPTMnet Report for P17096 (HMGA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17096 / HMGA1_HUMAN
Protein Name High mobility group protein HMG-I/HMG-Y
Gene Name Name: HMGA1
Synonyms:HMGIY;
Organism Homo sapiens (Human)

PRO ID PR:P17096
DAG View
PRO Name high mobility group protein HMG-I/HMG-Y (human)
Definition A high mobility group protein HMG-I/HMG-Y that is encoded in the genome of human.
Short Label hHMGA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17096 (HMGA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
K7 Acetylation PhosphoSitePlus
K7 Methylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus   UniProt 23186163
S14 Phosphorylation PhosphoSitePlus
K15 Acetylation PhosphoSitePlus   UniProt 19608861
K15 Methylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
K23 Methylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
R26 Methylation PhosphoSitePlus   UniProt 12653562, 15835918
K31 Acetylation PhosphoSitePlus
K31 Methylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S36 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 17081983, ...11593421, 17960875, 18847512, 31340016, 18669648, 24275569, 20068231, 17924679
S36 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor 17960875
S36 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 17960875, 18847512
S36 Phosphorylation Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor 17960875, 11593421
T39 Phosphorylation PhosphoSitePlus   UniProt 18669648, 24275569
V42 Phosphorylation UniProt 17960875, 21406692, 17924679
S44 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 17525332, 23186163, 18669648, ...24275569, 10617144
S44 Phosphorylation Q05655 (PRKCD) Signor 10617144
K46 Acetylation PhosphoSitePlus
K46 Methylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus   UniProt 18669648, 24275569
T53 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 11593421, ...15302935, 31340016, 1939057, 18669648, 17960875, 20068231, 17924679
T53 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17960875, 1939057
T53 Phosphorylation Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor 17960875, 11593421
K55 Acetylation PhosphoSitePlus
K55 Methylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
R58 Methylation PhosphoSitePlus   UniProt 16159886
R60 Methylation PhosphoSitePlus   UniProt 16159886
K62 Acetylation PhosphoSitePlus
K62 Methylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 10617144, 31340016
S64 Phosphorylation Q05655 (PRKCD) Signor 10617144
K65 Acetylation PhosphoSitePlus
K65 Methylation PhosphoSitePlus
K65 Sumoylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
K67 Methylation PhosphoSitePlus
K67 Phosphorylation UniProt 17960875
K71 Acetylation PhosphoSitePlus
K71 Methylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Methylation PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
T78 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11593421, 31340016, 15302935, ...1939057, 17960875, 12653562
T78 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17960875, 1939057
T78 Phosphorylation Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus 17960875, 11593421
R81 Methylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
R84 Methylation PhosphoSitePlus
R86 Methylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
S99 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 16083285, 15835918, ...17081983, 15302935, 31340016, 21406692, 2806554, 23186163, 19690332, 20068231
S102 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 16083285, 15835918, ...17081983, 15302935, 31340016, 21406692, 18669648, 2806554, 23186163, 28290473, 19690332, 20068231
S103 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 16083285, 15835918, ...17081983, 31340016, 15302935, 2806554, 23186163, 19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation HPRD 19413330, 19664995, 19651622, ...18669648, 14729942, 20068231, 17924679
T39 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S44 Phosphorylation HPRD 17525332, 19664995, 18452278, ...19651622, 18669648, 20068231
S49 Phosphorylation HPRD 14729942, 19651622, 18669648, ...20068231, 20068230
T53 Phosphorylation HPRD 19413330, 19664995, 1939057, ...18669648, 20068231, 17924679
T53 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 1939057, ...18669648, 20068231, 17924679
T78 Phosphorylation HPRD 1939057
T78 Phosphorylation P06493 (CDK1) HPRD 1939057
S99 Phosphorylation HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
S99 Phosphorylation P19784 (CSNK2A2) HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
S99 Phosphorylation P68400 (CSNK2A1) HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
S102 Phosphorylation HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S102 Phosphorylation P19784 (CSNK2A2) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S102 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S103 Phosphorylation HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S103 Phosphorylation P19784 (CSNK2A2) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S103 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K15 Acetylation PhosphoSitePlus
K15 Methylation PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
R26 Methylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S38 Phosphorylation HPRD   PhosphoSitePlus 14729942, 18669648, 20068231, ...20068230
T42 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17960875, 18234856, ...1939057, 18669648, 20068230, 20068231, 17924679
T42 Phosphorylation P06493 (CDK1) HPRD   PhosphoSitePlus 19413330, 18234856, 1939057, ...18669648, 17924679, 20068231, 20068230
T42 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus 17960875
K44 Acetylation PhosphoSitePlus
R45 Methylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
R49 Methylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
T67 Phosphorylation HPRD   PhosphoSitePlus 17960875, 1939057
T67 Phosphorylation P06493 (CDK1) HPRD 1939057
T67 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus 17960875
K71 Acetylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
K81 Methylation PhosphoSitePlus
S88 Phosphorylation HPRD   PhosphoSitePlus 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
S88 Phosphorylation P19784 (CSNK2A2) HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
S88 Phosphorylation P68400 (CSNK2A1) HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
S91 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S91 Phosphorylation P19784 (CSNK2A2) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S91 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S92 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S92 Phosphorylation P19784 (CSNK2A2) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
S92 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:P17096 (hHMGA1) PRO 10428834


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T21 N21 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R24 W24 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K44 N44 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R47 W47 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K55 N55 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R58 W58 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T75 I75 Biomuta [ cosmic ]
K88 N88 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]