iPTMnet Report for P16234 (PDGFRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16234 / PGFRA_HUMAN
Protein Name Platelet-derived growth factor receptor alpha precursor
Gene Name Name: PDGFRA
Synonyms:PDGFR2,RHEPDGFRA;
Organism Homo sapiens (Human)

PRO ID PR:P16234
DAG View
PRO Name platelet-derived growth factor receptor alpha (human)
Definition An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human.
Short Label hPDGFRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16234 (PDGFRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y288 Phosphorylation RLIMS-P 30389923
K378 Methylation PhosphoSitePlus
R554 Methylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
Y572 Phosphorylation P16234 (PDGFRA) phospho.ELM   PRO   PhosphoSitePlus   UniProt 10734113, 9454734, 11818394
Y574 Phosphorylation P16234 (PDGFRA) phospho.ELM   PRO   PhosphoSitePlus   UniProt 10734113, 9454734, 11818394
Y582 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
Y720 Phosphorylation P16234 (PDGFRA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 8943348, 11095946, 7523122, ...11818394
Y731 Phosphorylation P16234 (PDGFRA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 1646396, 7523122, 11818394
T739 Phosphorylation PhosphoSitePlus
T740 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation P16234 (PDGFRA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 1646396, 11818394, 7523122, ...30389923
S752 Phosphorylation PhosphoSitePlus
Y754 Phosphorylation P09619 (PDGFRB) , P16234 (PDGFRA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 25221952, 10417313, 7523122, ...17604334
S755 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation P16234 (PDGFRA) IntAct   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 9546424, 10733900
S767 Phosphorylation phospho.ELM   PhosphoSitePlus 8617789
Y768 Phosphorylation P16234 (PDGFRA) phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 8617789, 16497976
S847 Phosphorylation PhosphoSitePlus
Y849 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18083107
S851 Phosphorylation PhosphoSitePlus
Y926 Phosphorylation PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus
Y944 Phosphorylation PhosphoSitePlus
Y958 Phosphorylation PhosphoSitePlus
Y962 Phosphorylation PhosphoSitePlus
Y988 Phosphorylation P16234 (PDGFRA) phospho.ELM   PRO   PhosphoSitePlus   UniProt 7535778
T992 Phosphorylation PhosphoSitePlus
Y993 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
Y1018 Phosphorylation P16234 (PDGFRA) IntAct   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 7535778
S1041 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
S1080 Phosphorylation PhosphoSitePlus
S1081 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y720 Phosphorylation HPRD 8943348, 10837138
Y731 Phosphorylation HPRD 8943348
Y742 Phosphorylation HPRD 18578522, 8943348
Y754 Phosphorylation P16234 (PDGFRA) HPRD 7523122
Y762 Phosphorylation P16234 (PDGFRA) HPRD 9546424
S767 Phosphorylation HPRD 8617789
Y768 Phosphorylation HPRD 10837138
Y849 Phosphorylation HPRD 18083107, 18452278
S851 Phosphorylation HPRD 18452278
Y988 Phosphorylation P16234 (PDGFRA) HPRD 10837138, 7535778
Y993 Phosphorylation HPRD 10837138
Y1018 Phosphorylation P16234 (PDGFRA) HPRD 7535778


P16234 (PDGFRA) as PTM Enzyme



Substrate Site Score Source PMID
P12931 (SRC) Y419 PhosphoSitePlus   Signor 15489898
P16234 (PDGFRA) Y572 PhosphoSitePlus   UniProt 10734113, 9454734
P16234 (PDGFRA) Y574 PhosphoSitePlus   UniProt 10734113, 9454734
P16234 (PDGFRA) Y720 neXtProt   UniProt 7523122, 11095946
P16234 (PDGFRA) Y731 neXtProt   UniProt 1646396, 7523122
P16234 (PDGFRA) Y742 neXtProt   UniProt 1646396, 7523122
P16234 (PDGFRA) Y754 HPRD   UniProt 17604334, 7523122
P16234 (PDGFRA) Y762 HPRD   UniProt 10733900, 9546424
P16234 (PDGFRA) Y768 UniProt 8617789
P16234 (PDGFRA) Y988 HPRD   PhosphoSitePlus   UniProt 7535778, 10837138
P16234-1 (PDGFRA) Y1018 HPRD   PhosphoSitePlus   UniProt 7535778
Q05397 (PTK2) Y194 Signor 20802513


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048724 (hPDGFRA/SigPep-/Phos:1) pY572,pY574,pY720,pY731,pY742,pY754,pY762,pY768,pY849,pY988,pY1018 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y288 C288 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y288 H288 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y572 C572 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y574 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S584 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T739 A739 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T739 I739 Biomuta DOID:3571 / liver cancer [ cosmic ]
T740 A740 Biomuta DOID:363 / uterine cancer [ icgc ]
Y754 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S755 F755 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y762 H762 Biomuta DOID:3571 / liver cancer [ cosmic ]
S847 L847 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ]
S847 * Biomuta DOID:1319 / brain cancer [ cosmic ]
Y849 D849 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y849 C849 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S851 W851 Biomuta [ cosmic ]
S851 L851 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y944 H944 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y962 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1018 * Biomuta DOID:3277 / thymus cancer [ cosmic ]
S1041 C1041 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1041 N1041 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1042 L1042 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1080 Y1080 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1081 L1081 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]