iPTMnet Report P16234 PDGFRA

Protein Information

UniProt AC / UniProt ID	P16234 / PGFRA_HUMAN
Protein Name	Platelet-derived growth factor receptor alpha precursor
Gene Name	Name: PDGFRA Synonyms:PDGFR2,RHEPDGFRA;
Organism	Homo sapiens (Human)

PRO ID	PR:P16234 DAG View
PRO Name	platelet-derived growth factor receptor alpha (human)
Definition	An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human.
Short Label	hPDGFRA
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P16234 (PDGFRA) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y288	Phosphorylation		score0	RLIMS-P	30389923
K378	Methylation		score1	PhosphoSitePlus
R554	Methylation		score1	PhosphoSitePlus
S566	Phosphorylation		score1	PhosphoSitePlus
Y572	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus UniProt	10734113, 9454734, 11818394
Y572	Phosphorylation	P16234 (PDGFRA)	score4	PhosphoSitePlus UniProt	10734113, 9454734
Y574	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus UniProt	10734113, 9454734, 11818394
Y574	Phosphorylation	P16234 (PDGFRA)	score4	PhosphoSitePlus UniProt	10734113, 9454734
Y582	Phosphorylation		score1	PhosphoSitePlus
S584	Phosphorylation		score1	PhosphoSitePlus
K606	Ubiquitination		score1	PhosphoSitePlus
Y613	Phosphorylation		score1	PhosphoSitePlus
K638	Ubiquitination		score1	PhosphoSitePlus
S716	Phosphorylation		score1	PhosphoSitePlus
T717	Phosphorylation		score1	PhosphoSitePlus
Y720	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus UniProt	8943348, 11095946, 7523122, ...11818394
Y720	Phosphorylation	P16234 (PDGFRA)	score4	neXtProt UniProt	7523122, 11095946
Y731	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus UniProt	1646396, 7523122, 11818394
Y731	Phosphorylation	P16234 (PDGFRA)	score4	neXtProt UniProt	1646396, 7523122
T739	Phosphorylation		score1	PhosphoSitePlus
T740	Phosphorylation		score1	PhosphoSitePlus
Y742	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	1646396, 11818394, 7523122, ...30389923
Y742	Phosphorylation	P16234 (PDGFRA)	score4	neXtProt UniProt	1646396, 7523122
S752	Phosphorylation		score1	PhosphoSitePlus
Y754	Phosphorylation		score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	25221952, 10417313, 7523122, ...17604334
Y754	Phosphorylation	P09619 (PDGFRB)	score4	neXtProt PhosphoSitePlus	10417313, 7523122
Y754	Phosphorylation	P16234 (PDGFRA)	score2	UniProt	17604334
S755	Phosphorylation		score1	PhosphoSitePlus
S760	Phosphorylation		score1	PhosphoSitePlus
Y762	Phosphorylation		score4	IntAct phospho.ELM PRO PhosphoSitePlus UniProt	18083107, 9546424, 10733900
Y762	Phosphorylation	P16234 (PDGFRA)	score2	UniProt	10733900
S767	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	8617789
Y768	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus UniProt	18083107, 8617789, 16497976
Y768	Phosphorylation	P16234 (PDGFRA)	score2	UniProt	8617789
S847	Phosphorylation		score1	PhosphoSitePlus
Y849	Phosphorylation		score2	phospho.ELM PRO PhosphoSitePlus	18083107
S851	Phosphorylation		score1	PhosphoSitePlus
Y926	Phosphorylation		score1	PhosphoSitePlus
S935	Phosphorylation		score1	PhosphoSitePlus
Y944	Phosphorylation		score1	PhosphoSitePlus
Y958	Phosphorylation		score1	PhosphoSitePlus
Y962	Phosphorylation		score1	PhosphoSitePlus
Y988	Phosphorylation		score3	phospho.ELM PRO PhosphoSitePlus UniProt	7535778
Y988	Phosphorylation	P16234 (PDGFRA)	score3	PhosphoSitePlus UniProt	7535778
T992	Phosphorylation		score1	PhosphoSitePlus
Y993	Phosphorylation		score1	PhosphoSitePlus
S1016	Phosphorylation		score1	PhosphoSitePlus
Y1018	Phosphorylation		score4	IntAct phospho.ELM PRO PhosphoSitePlus UniProt	18083107, 7535778
Y1018	Phosphorylation	P16234 (PDGFRA)	score3	PhosphoSitePlus UniProt	7535778
S1041	Phosphorylation		score1	PhosphoSitePlus
S1042	Phosphorylation		score1	PhosphoSitePlus
S1048	Phosphorylation		score1	PhosphoSitePlus
S1080	Phosphorylation		score1	PhosphoSitePlus
S1081	Phosphorylation		score1	PhosphoSitePlus
S1087	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y720	Phosphorylation		score2	HPRD	8943348, 10837138
Y731	Phosphorylation		score1	HPRD	8943348
Y742	Phosphorylation		score2	HPRD	18578522, 8943348
Y754	Phosphorylation		score1	HPRD	7523122
Y754	Phosphorylation	P16234 (PDGFRA)	score1	HPRD	7523122
Y762	Phosphorylation		score1	HPRD	9546424
Y762	Phosphorylation	P16234 (PDGFRA)	score1	HPRD	9546424
S767	Phosphorylation		score1	HPRD	8617789
Y768	Phosphorylation		score1	HPRD	10837138
Y849	Phosphorylation		score0	HPRD	18083107, 18452278
S851	Phosphorylation		score0	HPRD	18452278
Y988	Phosphorylation		score2	HPRD	10837138, 7535778
Y988	Phosphorylation	P16234 (PDGFRA)	score2	HPRD	10837138, 7535778
Y993	Phosphorylation		score1	HPRD	10837138
Y1018	Phosphorylation		score1	HPRD	7535778
Y1018	Phosphorylation	P16234 (PDGFRA)	score1	HPRD	7535778

P16234 (PDGFRA) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P12931 (SRC)	Y419	score3	PhosphoSitePlus Signor	15489898
P16234 (PDGFRA)	Y572	score4	PhosphoSitePlus UniProt	10734113, 9454734
P16234 (PDGFRA)	Y574	score4	PhosphoSitePlus UniProt	10734113, 9454734
P16234 (PDGFRA)	Y720	score4	neXtProt UniProt	7523122, 11095946
P16234 (PDGFRA)	Y731	score4	neXtProt UniProt	1646396, 7523122
P16234 (PDGFRA)	Y742	score4	neXtProt UniProt	1646396, 7523122
P16234 (PDGFRA)	Y754	score4	HPRD UniProt	17604334, 7523122
P16234 (PDGFRA)	Y762	score4	HPRD UniProt	10733900, 9546424
P16234 (PDGFRA)	Y768	score2	UniProt	8617789
P16234 (PDGFRA)	Y988	score4	HPRD PhosphoSitePlus UniProt	7535778, 10837138
P16234-1 (PDGFRA)	Y1018	score3	HPRD PhosphoSitePlus UniProt	7535778
Q05397 (PTK2)	Y194	score1	Signor	20802513

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000048724 (hPDGFRA/SigPep-/Phos:1)	pY572,pY574,pY720,pY731,pY742,pY754,pY762,pY768,pY849,pY988,pY1018		PRO

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
Y288	C288	Biomuta	DOID:1319 / brain cancer [ cosmic ]
Y288	H288	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
Y572	C572	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y574	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S584	*	Biomuta	DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T739	A739	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T739	I739	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T740	A740	Biomuta	DOID:363 / uterine cancer [ icgc ]
Y754	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S755	F755	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y762	H762	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S847	L847	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ]
S847	*	Biomuta	DOID:1319 / brain cancer [ cosmic ]
Y849	D849	Biomuta	DOID:1319 / brain cancer [ cosmic ]
Y849	C849	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S851	W851	Biomuta	[ cosmic ]
S851	L851	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y944	H944	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y962	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y1018	*	Biomuta	DOID:3277 / thymus cancer [ cosmic ]
S1041	C1041	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S1041	N1041	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S1042	L1042	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S1080	Y1080	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S1081	L1081	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P16234 (PDGFRA)

Protein Information

Interactive Sequence View

P16234 (PDGFRA) as Substrate

P16234 (PDGFRA) as PTM Enzyme

Proteoforms

PTM sites affected in variants