iPTMnet Report for P16220 (CREB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16220 / CREB1_HUMAN
Protein Name Cyclic AMP-responsive element-binding protein 1
Gene Name Name: CREB1
Organism Homo sapiens (Human)

PRO ID PR:P16220
DAG View
PRO Name cyclic AMP-responsive element-binding protein 1 (human)
Definition A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human.
Short Label hCREB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16220 (CREB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation RLIMS-P 32128390
S40 O-Glycosylation GlyGen 23301498, 33214551, 24140293, ...35138101, 34019948, 25813380, 30709903, 29351928, 18057713, 35132862, 30169966, 32119511, 20863279, 15327282
T47 O-Glycosylation GlyGen 23301498, 33214551, 24140293, ...35138101, 34019948, 30709903, 29351928, 18057713, 35132862, 30169966, 32119511, 20863279, 15327282
S48 O-Glycosylation GlyGen 23301498, 33214551, 24140293, ...35138101, 34019948, 30709903, 29351928, 18057713, 35132862, 30169966, 32119511, 20863279, 15327282
S49 O-Glycosylation GlyGen 23301498, 33214551, 24140293, ...35138101, 34019948, 30709903, 29351928, 18057713, 35132862, 30169966, 32119511, 20863279, 15327282
T52 O-Glycosylation GlyGen 23301498, 33214551, 24140293, ...35138101, 34019948, 30709903, 29351928, 18057713, 35132862, 30169966, 32119511, 20863279, 15327282
T54 O-Glycosylation GlyGen 23301498, 33214551, 24140293, ...35138101, 34019948, 30709903, 29351928, 18057713, 35132862, 30169966, 32119511, 20863279, 15327282
S80 Phosphorylation RLIMS-P 28338624
S94 Phosphorylation PhosphoSitePlus   Signor 9931297
S94 Phosphorylation P48729 (CSNK1A1) Signor 9931297
S97 Phosphorylation PhosphoSitePlus   Signor 15073328, 9931297
S97 Phosphorylation P48729 (CSNK1A1) Signor 9931297
S97 Phosphorylation Q13315 (ATM) Signor 15073328
S100 Phosphorylation PhosphoSitePlus   Signor 9931297
S100 Phosphorylation P48729 (CSNK1A1) Signor 9931297
S103 Phosphorylation PhosphoSitePlus   RLIMS-P 16782881
T105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 15073328, 16782881
S107 Phosphorylation Q13315 (ATM) Signor 15073328
S107 Phosphorylation Q13535 (ATR) Signor 15073328
S115 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 15733869, 8887554, 7608156, ...17668895, 7536740, 9687510, 8384857, 12835716, 20626350, 9770464, 15711594, 15964553, 8688081, 17389598, 10558990, 9829964, 8065343
S119 Phosphorylation O75582 (RPS6KA5) Signor 9687510
S119 Phosphorylation O75676 (RPS6KA4) Signor 17668895
S119 Phosphorylation P31749 (AKT1) Signor 9829964
S119 Phosphorylation P31751 (AKT2) Signor 9829964
S119 Phosphorylation P49137 (MAPKAPK2) Signor 20626350, 17389598, 8887554
S119 Phosphorylation P51812 (RPS6KA3) Signor 8688081
S119 Phosphorylation Q15418 (RPS6KA1) Signor 10558990
S119 Phosphorylation Q16566 (CAMK4) Signor 17389598, 12835716
S119 Phosphorylation Q6SA08 (TSSK4) Signor 15964553
S119 Phosphorylation Q9Y243 (AKT3) Signor 9829964
Y120 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus   UniProt 23186163
S129 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 11796524, 20541704, 15073527, ...7798217, 9668047, 18801732
S129 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 20541704
S142 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 7958915, 11013247, 9668047, ...33324330, 22554507, 24106266, 11970864, 11970866
S142 Phosphorylation Q13557 (CAMK2D) neXtProt 22554507
S142 Phosphorylation Q9UQM7 (CAMK2A) Signor 11970864, 9668047, 11013247
T196 Phosphorylation RLIMS-P 24952642
T242 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   Signor   UniProt 20573984
S257 Phosphorylation Q9H2X6 (HIPK2) Signor 20573984
K271 Sumoylation PhosphoSitePlus
K290 Sumoylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
C296 Methylation IEDB 31844290
R300 Methylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
C323 Methylation IEDB 31844290
K325 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K91 Acetylation PRO 12595525
K91 Acetylation PR:Q92793 (hCREBBP) PRO 12595525
K94 Acetylation PRO 12595525
K94 Acetylation PR:Q92793 (hCREBBP) PRO 12595525
S98 Phosphorylation PhosphoSitePlus
T100 Phosphorylation HPRD   PhosphoSitePlus 15073328
T100 Phosphorylation Q13315 (ATM) HPRD 15073328
S111 Phosphorylation HPRD 15073328
S111 Phosphorylation Q13315 (ATM) HPRD 15073328
T119 Phosphorylation HPRD 17525332
S121 Phosphorylation HPRD 15073328, 16293623
S121 Phosphorylation Q13315 (ATM) HPRD 15073328, 16293623
S129 Phosphorylation HPRD 12162494
S129 Phosphorylation P49841 (GSK3B) HPRD 12162494
S133 Phosphorylation HPRD   PhosphoSitePlus 15733869, 8688081, 11160957, ...11018520, 11909979, 15964553, 11175347, 15466214, 12235136, 9687510, 8887554, 11698596, 9829964
S133 Phosphorylation O00141 (SGK1) HPRD 15733869
S133 Phosphorylation O75582 (RPS6KA5) HPRD 11018520, 11909979, 9687510
S133 Phosphorylation O75676 (RPS6KA4) HPRD 11175347, 9687510, 8688081, ...9829964
S133 Phosphorylation P31749 (AKT1) HPRD 9829964
S133 Phosphorylation P49137 (MAPKAPK2) HPRD 8887554
S133 Phosphorylation P51812 (RPS6KA3) HPRD 11175347, 9687510, 8688081, ...11160957, 9829964
S133 Phosphorylation Q13976 (PRKG1) HPRD 11175347, 9687510, 8688081, ...9829964
S133 Phosphorylation Q15349 (RPS6KA2) HPRD 11175347, 11698596, 8688081, ...9829964, 9687510
S133 Phosphorylation Q15418 (RPS6KA1) HPRD 11175347, 9687510, 9829964, ...12235136, 8688081
S133 Phosphorylation Q6SA08 (TSSK4) HPRD 15964553
K136 Acetylation PRO 12595525
K136 Acetylation PR:Q92793 (hCREBBP) PRO 12595525
S142 Phosphorylation HPRD 20058876, 18452278
S270 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S97 Phosphorylation HPRD 15073328
S97 Phosphorylation Q13315 (ATM) HPRD 15073328
S107 Phosphorylation HPRD 15073328
S107 Phosphorylation Q13315 (ATM) HPRD 15073328
S115 Phosphorylation HPRD 12162494
S115 Phosphorylation P49841 (GSK3B) HPRD 12162494
S119 Phosphorylation HPRD 11175347, 15733869, 9687510, ...8688081, 9829964
S119 Phosphorylation O00141 (SGK1) HPRD 15733869
S128 Phosphorylation HPRD 20058876, 18452278
S256 Phosphorylation HPRD 18669648, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028641 (hCREB1/iso:1/Ac:1) acK91,acK94,acK136 PR:Q92793 (hCREBBP) PRO 12595525


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q53ET0 (CRTC2) S171 P16220 (CREB1) inhibited_association eFIP 33000695


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T47 A47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S48 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T52 I52 Biomuta DOID:4159 / skin cancer [ cosmic ]
S80 F80 Biomuta DOID:4159 / skin cancer [ cosmic ]
S103 N103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R300 K300 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K316 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K316 E316 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
C323 Y323 Biomuta DOID:10534 / stomach cancer [ cosmic ]