Protein Information

Cytoscape View


UniProt AC / UniProt ID P16220 / CREB1_HUMAN
Protein Name Cyclic AMP-responsive element-binding protein 1
Gene Name Name: CREB1
Organism Homo sapiens (Human)

PRO ID PR:P16220
DAG View
PRO Name cyclic AMP-responsive element-binding protein 1 (human)
Definition A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human.
Short Label hCREB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16220 (CREB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation RLIMS-P 22267118
S80 Phosphorylation RLIMS-P 28338624
S98 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus 17389598
T100 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   Signor 15073328
S108 Phosphorylation P68400 (CSNK2A1) , P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P   Signor 20730097, 17209043, 9931297, ...19336000
S111 Phosphorylation P68400 (CSNK2A1) , P48729 (CSNK1A1) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17525332, 17209043, 15073328, ...9931297, 19336000, 20730097
S114 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P   Signor 20730097, 17209043, 9931297, ...19336000
S117 Phosphorylation PhosphoSitePlus   RLIMS-P 17209043
T119 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S121 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17209043, 18372325, 15073328, ...16293623, 20730097, 27409833
S129 Phosphorylation P49841 (GSK3B) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 11796524, 20541704, 7798217, ...9668047, 15073527, 25412261
S133 Phosphorylation Q16539 (MAPK14) , P31751 (AKT2) , Q02156 (PRKCE) , O43781 (DYRK3) , Q96NX5 (CAMK1G) , Q16566 (CAMK4) , P17612 (PRKACA) , Q6SA08 (TSSK4) , Q99986 (VRK1) , Q13557 (CAMK2D) , Q15418 (RPS6KA1) , O75676 (RPS6KA4) , P28482 (MAPK1) , Q14012 (CAMK1) , Q06187 (BTK) , P51812 (RPS6KA3) , Q13627 (DYRK1A) , O75582 (RPS6KA5) , P41279 (MAP3K8) , O00141 (SGK1) , P27361 (MAPK3) , P31749 (AKT1) , Q13315 (ATM) , Q15349 (RPS6KA2) , Q9Y243 (AKT3) , P49137 (MAPKAPK2) , Q15139 (PRKD1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 8336722, 12637513, 27191986, ...12567184, 10886376, 15967875, 9687510, 27397543, 12356771, 10598580, 10567368, 8816467, 28627368, 24201813, 15917193, 11956329, 11969286, 23196462, 8205620, 12810757, 10200909, 15733869, 15515068, 25927309, 7958915, 12372763, 9688563, 9228071, 10684253, 21488836, 19008230, 17276404, 11535812, 12391146, 15689550, 24113161, 14597636, 11909979, 8721007, 1646483, 7608156, 11391701, 18263767, 17183642, 11406182, 12393305, 12773552, 21853033, 20191585, 14536081, 9492053, 19804365, 18310282, 27411738, 19070599, 15753290, 29434603, 26388727, 17579344, 22740515, 19340314, 8621702, 17209043, 22267118, 15319449, 9770464, 9558095, 12835716, 7862172, 9167959, 8028671, 26274502, 20979795, 1840296, 21680899, 11158288, 9366390, 11511407, 17128269, 24240687, 20198332, 11403878, 20089855, 10386963, 28374824, 8977178, 7551568, 24792438, 16761278, 21308733, 19223597, 7910846, 27095572, 19910110, 20824729, 11160957, 16817901, 17449469, 20685939, 11701463, 15389611, 10856237, 20101207, 10669737, 20303596, 20178980, 28593137, 18657608, 9822730, 24590896, 22761932, 17127423, 29228623, 21569106, 25389293, 11487623, 25883219, 23532963, 11902114, 20015475, 11013247, 11495901, 20693566, 23102993, 8702497, 19172190, 22506514, 9829964, 23643942, 23143030, 27010597, 24769103, 8887554, 27816995, 19369332, 20805990, 8552098, 22493319, 18372325, 9753174, 12665587, 1671708, 22669896, 7906413, 11970860, 11698596, 28469516, 11970864, 11278709, 8065343, 23902294, 15155564, 11591753, 20952540, 27527859, 11950843, 26843422, 25921811, 22227470, 25882230, 20943963, 8754745, 17426037, 16652169, 16500891, 25412261, 11226322, 19710943, 19859966, 24416428, 15138445, 23185487, 23953193, 8688081, 21302324, 8683108, 10558990, 25605239, 16169904, 15964553, 16339038, 18160048, 18310090, 26008971, 11483647, 23814058, 17270176, 11156964, 9077542, 25617893, 27339399, 23241891, 10067851, 23575689, 7864890, 21156805, 9893043, 16945922, 16246306, 17565599, 11445280, 11123304, 14980726, 23341039, 9657746, 12805224, 21619646, 23494562, 27884605, 18180320, 21826707, 17389598, 20370681, 19089619, 23531616, 10872467, 11518709, 10966485, 24302736, 15337521, 28428044, 18303947, 26728351, 25870199, 9668047, 21072193, 1832337, 18713830, 28338624, 14962944, 26743006, 17548807, 14645681, 28779377, 11723177, 15030385, 18690222, 19898718, 20484048, 16517600, 17429437, 27036119, 25404345, 26733416, 8125987, 10722651, 8576192, 7876182, 29559698, 24038359, 25277185, 10652539, 16532028, 27372058, 20497126, 15855407, 12210727, 17178914, 8704240, 15149291, 14769862, 17210223, 17631291, 12559097, 21109534, 22403610, 9482882, 22554507, 27933067, 15302573, 25451221, 17325033, 17200689, 11085926, 20573984, 19738069, 23516971, 18070920, 12163549, 9528766, 15585582, 19620255, 24979279, 26398148, 8530445, 24618420, 15659240, 27211267, 8097062, 23404502, 18036509, 29709472, 21236315, 21516343, 18204156, 17668895, 8195196, 11483246, 8980227, 23407882, 21302281, 7479832, 20626350, 8982161, 17091402, 21623792, 26870802, 28079521, 24701590, 16172130, 11970866, 12235793, 9087428, 24952642, 27409833, 11094091, 25781725, 23449452
Y134 Phosphorylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S142 Phosphorylation Q9UQM7 (CAMK2A) , Q13557 (CAMK2D) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 15389611, 7958915, ...11013247, 9668047, 17574346, 22554507, 24106266, 11970864, 11970866
S143 Phosphorylation PhosphoSitePlus   RLIMS-P 15389611, 11970864
S156 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 8552098
T256 Phosphorylation PhosphoSitePlus
S270 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 23814058
S271 Phosphorylation Q9H2X6 (HIPK2) , P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20573984, 27884605, 23814058
K285 Sumoylation PhosphoSitePlus
K304 Sumoylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
R314 Methylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K91 Acetylation PR:Q92793 (hCREBBP) PRO 12595525
K94 Acetylation PR:Q92793 (hCREBBP) PRO 12595525
T100 Phosphorylation Q13315 (ATM) HPRD 15073328
S111 Phosphorylation Q13315 (ATM) HPRD 15073328
T119 Phosphorylation HPRD 17525332
S121 Phosphorylation Q13315 (ATM) HPRD 15073328, 16293623
S129 Phosphorylation P49841 (GSK3B) HPRD 12162494
S133 Phosphorylation O75582 (RPS6KA5) , P49137 (MAPKAPK2) , P51812 (RPS6KA3) , Q6SA08 (TSSK4) , Q15349 (RPS6KA2) , P31749 (AKT1) , Q15418 (RPS6KA1) , O75676 (RPS6KA4) , O00141 (SGK1) , Q13976 (PRKG1) HPRD 15733869, 8688081, 11160957, ...11018520, 11909979, 15964553, 11175347, 15466214, 12235136, 9687510, 8887554, 11698596, 9829964
K136 Acetylation PR:Q92793 (hCREBBP) PRO 12595525
S142 Phosphorylation HPRD 20058876, 18452278
S270 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S97 Phosphorylation Q13315 (ATM) HPRD 15073328
S107 Phosphorylation Q13315 (ATM) HPRD 15073328
S115 Phosphorylation P49841 (GSK3B) HPRD 12162494
S119 Phosphorylation O00141 (SGK1) HPRD 11175347, 15733869, 9687510, ...8688081, 9829964
S128 Phosphorylation HPRD 20058876, 18452278
S256 Phosphorylation HPRD 18669648, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028641 (hCREB1/iso:1/Ac:1) acK91,acK94,acK136 PR:Q92793 (hCREBBP) PRO 12595525


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P16220 (CREB1) S133 Q92793 (CREBBP) increased_association eFIP 7479832
Phosphorylation P16220 (CREB1) S142 Q92793 (CREBBP) decreased_association eFIP 22554507
Phosphorylation P16220 (CREB1) S121 Q92793 (CREBBP) decreased_association eFIP 20573984


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R314 K314 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]