iPTMnet Report P16070 CD44

Protein Information

UniProt AC / UniProt ID	P16070 / CD44_HUMAN
Protein Name	CD44 antigen precursor
Gene Name	Name: CD44 Synonyms:LHR,MDU2,MDU3,MIC4;
Organism	Homo sapiens (Human)

PRO ID	PR:P16070 DAG View
PRO Name	CD44 antigen (human)
Definition	A CD44 molecule that is encoded in the genome of human.
Short Label	hCD44
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P16070 (CD44) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
N25	N-Glycosylation		score1	GlyGen	29741879
S45	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
K54	Ubiquitination		score1	PhosphoSitePlus
N57	N-Glycosylation		score2	GlyGen UniProt	16335952, 30237853, 19159218, ...24190977, 23090970, 29391424, 29741879
S58	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T62	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
N100	N-Glycosylation		score2	GlyGen	22722744
N110	N-Glycosylation		score2	GlyGen UniProt	19159218
K158	Ubiquitination		score1	PhosphoSitePlus
T163	Phosphorylation		score1	PhosphoSitePlus
S171	Phosphorylation		score1	PhosphoSitePlus
T174	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
S179	Phosphorylation		score1	PhosphoSitePlus
S180	O-Glycosylation		score2	GlyGen UniProt	25326458, 36213313, 32337544
S182	Phosphorylation		score1	PhosphoSitePlus
S183	Phosphorylation		score1	PhosphoSitePlus
S184	Phosphorylation		score1	PhosphoSitePlus
T197	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S199	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 30459171, 25813380
T200	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 30459171, 25813380
T222	Phosphorylation		score1	PhosphoSitePlus
T271	O-Glycosylation		score1	GlyGen	30459171
N282	N-Glycosylation		score1	GlyGen	24190977
S291	Phosphorylation		score4	phospho.ELM RLIMS-P	12032545, 32697798
T311	Phosphorylation		score1	PhosphoSitePlus
T318	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T325	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S330	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S332	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
N350	N-Glycosylation		score1	GlyGen	24190977
T398	O-Glycosylation		score1	GlyGen	30459171
Y412	O-Glycosylation		score1	GlyGen	23584533, 25813380
Y412	Phosphorylation		score1	PhosphoSitePlus
T415	O-Glycosylation		score1	GlyGen	23584533
S420	O-Glycosylation		score1	GlyGen	25813380
S420	Phosphorylation		score1	PhosphoSitePlus
S422	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T423	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T424	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T426	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S430	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T433	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S434	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S458	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S478	O-Glycosylation		score1	GlyGen	23584533
T480	O-Glycosylation		score1	GlyGen	23584533
T484	O-Glycosylation		score1	GlyGen	23584533, 30459171
T489	O-Glycosylation		score1	GlyGen	23584533, 30459171
S514	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
T515	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
T528	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
T529	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
T541	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
N548	N-Glycosylation		score1	GlyGen	24190977
S550	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S553	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T554	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 30459171, 25813380
T555	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
Y560	O-Glycosylation		score3	GlyGen	23584533, 23399548, 25813380
T561	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S562	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
Y564	O-Glycosylation		score1	GlyGen	25813380
T567	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S570	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T572	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T572	Phosphorylation		score1	PhosphoSitePlus
T577	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S578	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T581	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
S583	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
T587	Phosphorylation		score1	PhosphoSitePlus
N595	N-Glycosylation		score1	GlyGen	24190977
N597	N-Glycosylation		score1	GlyGen	24190977
N599	N-Glycosylation		score1	GlyGen	24190977
S627	O-Glycosylation		score1	GlyGen	30459171
T637	O-Glycosylation		score1	GlyGen	25813380, 22171320
T638	O-Glycosylation		score1	GlyGen	25813380, 22171320
S672	Phosphorylation	P17252 (PRKCA)	score3	phospho.ELM PhosphoSitePlus UniProt	12032545
K681	Acetylation		score1	PhosphoSitePlus
K681	Ubiquitination		score1	PhosphoSitePlus
S686	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 17081983, ...20068231
K695	Ubiquitination		score1	PhosphoSitePlus
S697	Phosphorylation	P17612 (PRKACA)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	18669648, 16785995, 17081983
S704	Phosphorylation		score1	PhosphoSitePlus
K705	Ubiquitination		score1	PhosphoSitePlus
S706	Phosphorylation	Q9UQM7 (CAMK2A)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	18691976, 21406692, 23186163, ...17081983, 12032545, 9580567, 19367720, 18669648, 20068231, 11463356
K715	Ubiquitination		score1	PhosphoSitePlus
S717	Phosphorylation		score1	PhosphoSitePlus
S718	Phosphorylation		score1	PhosphoSitePlus
T720	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17081983
T726	Phosphorylation		score1	PhosphoSitePlus
K739	Ubiquitination		score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
S45	Phosphorylation	score0	HPRD	18669648
S58	Phosphorylation	score0	HPRD	18669648
T62	Phosphorylation	score0	HPRD	18669648
T587	Phosphorylation	score0	HPRD	18452278
S672	Phosphorylation	score1	HPRD	12032545
S686	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231
S697	Phosphorylation	score0	HPRD	20068231, 18077418, 18669648, ...18578522
S704	Phosphorylation	score0	HPRD	18578522, 20068231
S706	Phosphorylation	score2	HPRD	18691976, 18578522, 12032545, ...9580567, 18077418, 18707149, 18452278, 19651622, 18669648, 18767875, 20068231, 11463356
S717	Phosphorylation	score0	HPRD	20068231, 18452278
S718	Phosphorylation	score0	HPRD	18578522, 18452278
T720	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231

Site	PTM Type	Score	Source	PMID
S45	Phosphorylation	score0	HPRD	18669648
S58	Phosphorylation	score0	HPRD	18669648
T62	Phosphorylation	score0	HPRD	18669648
T338	Phosphorylation	score0	HPRD	18452278
S423	Phosphorylation	score1	HPRD	12032545
S437	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231
S448	Phosphorylation	score0	HPRD	20068231, 18077418, 18669648, ...18578522
S455	Phosphorylation	score0	HPRD	18578522, 20068231
S457	Phosphorylation	score2	HPRD	18691976, 18578522, 12032545, ...9580567, 18077418, 18707149, 18452278, 19651622, 18669648, 18767875, 20068231, 11463356
S468	Phosphorylation	score0	HPRD	20068231, 18452278
S469	Phosphorylation	score0	HPRD	18578522, 18452278
T471	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231

Site	PTM Type	Score	Source	PMID
S45	Phosphorylation	score0	HPRD	18669648
S58	Phosphorylation	score0	HPRD	18669648
T62	Phosphorylation	score0	HPRD	18669648
S291	Phosphorylation	score3	HPRD PhosphoSitePlus	12032545
S305	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231
S316	Phosphorylation	score0	HPRD	20068231, 18077418, 18669648, ...18578522
S323	Phosphorylation	score0	HPRD	18578522, 20068231
S325	Phosphorylation	score4	HPRD PhosphoSitePlus	18691976, 18578522, 12032545, ...9580567, 18077418, 18707149, 18452278, 19651622, 18669648, 18767875, 20068231, 11463356
S336	Phosphorylation	score0	HPRD	20068231, 18452278
S337	Phosphorylation	score0	HPRD	18578522, 18452278
T339	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231

Site	PTM Type	Score	Source	PMID
S45	Phosphorylation	score0	HPRD	18669648
S58	Phosphorylation	score0	HPRD	18669648
T62	Phosphorylation	score0	HPRD	18669648

Site	PTM Type	Score	Source	PMID
S45	Phosphorylation	score0	HPRD	18669648
S58	Phosphorylation	score0	HPRD	18669648
T62	Phosphorylation	score0	HPRD	18669648
T544	Phosphorylation	score0	HPRD	18452278
S629	Phosphorylation	score1	HPRD	12032545
S643	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231
S654	Phosphorylation	score0	HPRD	20068231, 18077418, 18669648, ...18578522
S661	Phosphorylation	score0	HPRD	18578522, 20068231
S663	Phosphorylation	score2	HPRD	18691976, 18578522, 12032545, ...9580567, 18077418, 18707149, 18452278, 19651622, 18669648, 18767875, 20068231, 11463356
S674	Phosphorylation	score0	HPRD	20068231, 18452278
S675	Phosphorylation	score0	HPRD	18578522, 18452278
T677	Phosphorylation	score0	HPRD	18578522, 18669648, 20068231

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P35240 (NF2)	S518	P16070 (CD44)	unknown	eFIP	19141242

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
T174	I174	Biomuta	DOID:363 / uterine cancer [ cosmic ]
S180	R180	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S182	F182	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S199	C199	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S291	R291	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S291	T291	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S330	I330	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
S430	L430	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S458	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T480	M480	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S553	*	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
T554	A554	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
Y564	C564	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
T567	M567	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T581	I581	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
N597	T597	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
N599	S599	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
K715	N715	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P16070 (CD44)

Protein Information

Interactive Sequence View

P16070 (CD44) as Substrate

PTM-dependent PPI

PTM sites affected in variants