iPTMnet Report for P15170 (GSPT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15170 / ERF3A_HUMAN
Protein Name Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Gene Name Name: GSPT1
Synonyms:ERF3A;
Organism Homo sapiens (Human)

PRO ID PR:P15170
DAG View
PRO Name eukaryotic peptide chain release factor GTP-binding subunit ERF3A (human)
Definition A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.
Short Label hGSPT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15170 (GSPT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Methylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
C407 Methylation IEDB 31844290
S436 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 34019948, 28510447
K448 Ubiquitination PhosphoSitePlus
C453 S-Nitrosylation dbSNO 19483679, 26338901
C464 Methylation IEDB 31844290
K469 Acetylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
T478 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K490 Acetylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K493 Acetylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
R91 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 R17 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y109 H109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y146 H146 Biomuta DOID:263 / kidney cancer [ cosmic ]
T192 S192 Biomuta DOID:3571 / liver cancer [ cosmic ]