iPTMnet Report for P14868 (DARS1)
Protein Information
UniProt AC / UniProt ID | P14868 / SYDC_HUMAN |
Protein Name | Aspartate--tRNA ligase, cytoplasmic |
Gene Name | Name: DARS1 Synonyms:DARS;ORFNames:PIG40; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P14868 |
PRO Name | aspartate--tRNA ligase, cytoplasmic (human) |
Definition | An aspartate--tRNA ligase, cytoplasmic that is encoded in the genome of human. |
Short Label | hDARS1 |
Category | organism-gene |
P14868 (DARS1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y24 | Phosphorylation | score1 | PhosphoSitePlus | |||
K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
K40 | Ubiquitination | score1 | PhosphoSitePlus | |||
R43 | Methylation | score1 | PhosphoSitePlus | |||
T52 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K55 | Acetylation | score1 | PhosphoSitePlus | |||
R63 | Methylation | score1 | PhosphoSitePlus | |||
K74 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
K103 | Acetylation | score1 | PhosphoSitePlus | |||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
K110 | Acetylation | score1 | PhosphoSitePlus | |||
K110 | Ubiquitination | score1 | PhosphoSitePlus | |||
S112 | Phosphorylation | score1 | PhosphoSitePlus | |||
K126 | Ubiquitination | score1 | PhosphoSitePlus | |||
S146 | Phosphorylation | score1 | PhosphoSitePlus | |||
R188 | Methylation | score1 | PhosphoSitePlus | |||
S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
K213 | Acetylation | score1 | PhosphoSitePlus | |||
T220 | Phosphorylation | score1 | PhosphoSitePlus | |||
S225 | Phosphorylation | score1 | PhosphoSitePlus | |||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y239 | Phosphorylation | score1 | PhosphoSitePlus | |||
K241 | Acetylation | score1 | PhosphoSitePlus | |||
K241 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y245 | Phosphorylation | score1 | PhosphoSitePlus | |||
S249 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163 | ||
Y253 | Phosphorylation | score1 | PhosphoSitePlus | |||
K254 | Acetylation | score1 | PhosphoSitePlus | |||
K330 | Acetylation | score1 | PhosphoSitePlus | |||
K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
C334 | Methylation | score1 | IEDB | 31844290 | ||
K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
T343 | Phosphorylation | score1 | PhosphoSitePlus | |||
S369 | Phosphorylation | score1 | PhosphoSitePlus | |||
T370 | Phosphorylation | score1 | PhosphoSitePlus | |||
K374 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K374 | Ubiquitination | score1 | PhosphoSitePlus | |||
K381 | Ubiquitination | score1 | PhosphoSitePlus | |||
K383 | Acetylation | score1 | IEDB | 34357683 | ||
K383 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y384 | Phosphorylation | score1 | PhosphoSitePlus | |||
T386 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y389 | Phosphorylation | score1 | PhosphoSitePlus | |||
K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y394 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y402 | Phosphorylation | score1 | PhosphoSitePlus | |||
T403 | Phosphorylation | score1 | PhosphoSitePlus | |||
K411 | Ubiquitination | score1 | PhosphoSitePlus | |||
S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
K451 | Acetylation | score1 | PhosphoSitePlus | |||
K451 | Ubiquitination | score1 | PhosphoSitePlus | |||
K453 | Acetylation | score1 | PhosphoSitePlus | |||
K453 | Ubiquitination | score1 | PhosphoSitePlus | |||
T500 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S146 | Phosphorylation | score0 | HPRD | 20068231 | ||
S225 | Phosphorylation | score0 | HPRD | 20068231 | ||
T236 | Phosphorylation | score0 | HPRD | 20068231 | ||
S238 | Phosphorylation | score0 | HPRD | 17322306 | ||
S249 | Phosphorylation | score0 | HPRD | 19413330, 18767875, 19664994, ... | ||
Y253 | Phosphorylation | score0 | HPRD | 19413330 | ||
T323 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S10 | C10 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R43 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] | |
R63 | P63 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
R63 | C63 | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
K103 | T103 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R188 | W188 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K213 | I213 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S225 | L225 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y253 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K254 | E254 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K330 | T330 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K338 | T338 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
Y394 | C394 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
T500 | I500 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |