Protein Information

Cytoscape View


UniProt AC / UniProt ID P14868 / SYDC_HUMAN
Protein Name Aspartate--tRNA ligase, cytoplasmic
Gene Name Name: DARS1
Synonyms:DARS;ORFNames:PIG40;
Organism Homo sapiens (Human)

PRO ID PR:P14868
DAG View
PRO Name aspartate--tRNA ligase, cytoplasmic (human)
Definition An aspartate--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hDARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14868 (DARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
R43 Methylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus   UniProt 23186163
K55 Acetylation PhosphoSitePlus
R63 Methylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus   UniProt 19608861
K74 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Y253 Phosphorylation PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
K374 Acetylation PhosphoSitePlus   UniProt 19608861
K374 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S146 Phosphorylation HPRD 20068231
S225 Phosphorylation HPRD 20068231
T236 Phosphorylation HPRD 20068231
S238 Phosphorylation HPRD 17322306
S249 Phosphorylation HPRD 19413330, 18767875, 19664994, ...19664995
Y253 Phosphorylation HPRD 19413330
T323 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 C10 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R43 * Biomuta DOID:1612 / breast cancer [ tcga ]
R63 P63 Biomuta DOID:1324 / lung cancer [ cosmic ]
R188 W188 Biomuta DOID:1909 / melanoma [ cosmic ]
K213 I213 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y253 * Biomuta DOID:363 / uterine cancer [ tcga ]
K330 T330 Biomuta DOID:363 / uterine cancer [ tcga ]
K338 T338 Biomuta DOID:363 / uterine cancer [ tcga ]
S369 R369 Biomuta DOID:3571 / liver cancer [ icgc ]
Y394 C394 Biomuta DOID:5041 / esophageal cancer [ icgc ]