iPTMnet Report for P14859 (POU2F1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14859 / PO2F1_HUMAN
Protein Name POU domain, class 2, transcription factor 1
Gene Name Name: POU2F1
Synonyms:OCT1,OTF1;
Organism Homo sapiens (Human)

PRO ID PR:P14859
DAG View
PRO Name POU domain, class 2, transcription factor 1 (human)
Definition A POU domain, class 2, transcription factor 1 that is encoded in the genome of human.
Short Label hPOU2F1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14859 (POU2F1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S78 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S81 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S81 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S85 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S85 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S88 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S88 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S92 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S92 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
T100 Phosphorylation neXtProt   PhosphoSitePlus 17213819
T100 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S141 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S141 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S143 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S143 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S147 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S147 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
T162 Phosphorylation neXtProt   PhosphoSitePlus 17213819
T162 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
S167 Phosphorylation neXtProt   PhosphoSitePlus 17213819
S167 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 17213819
T226 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T226 Phosphorylation neXtProt   PhosphoSitePlus   Signor 17213819, 9368058
T226 Phosphorylation P78527 (PRKDC) PhosphoSitePlus   Signor 17213819, 9368058
S232 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
S232 Phosphorylation neXtProt   PhosphoSitePlus   Signor 17213819, 9368058
S232 Phosphorylation P78527 (PRKDC) PhosphoSitePlus   Signor 17213819, 9368058
S242 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T251 Phosphorylation PhosphoSitePlus
T255 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 29237092, 23580612, 30397120, 32119511, 31637018, 32938750, 35132862, 20305658, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T255 Phosphorylation PhosphoSitePlus
T259 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 34846842, 23580612, 20305658, 30397120, 35132862, 31637018, 30059200, 34019948, 21740066, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T259 Phosphorylation PhosphoSitePlus
T263 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T263 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S269 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
S269 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18847512
S269 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T270 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512
T270 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
T276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S278 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K293 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S335 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 21897860, 25937278, 27407111
S335 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 25937278
S335 Phosphorylation Q9HC98 (NEK6) neXtProt 21897860
S335 Phosphorylation Q9Y478 (PRKAB1) PhosphoSitePlus 25937278
S366 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S385 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 1684878, 9368058
S385 Phosphorylation P17612 (PRKACA) neXtProt 1684878
S385 Phosphorylation P50613 (CDK7) phospho.ELM 9368058
S385 Phosphorylation Q13131 (PRKAA1) Signor 9368058, 1684878
S442 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T445 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S448 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 15302935, ...23186163
S535 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T725 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
S728 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
S730 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
S734 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T735 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T736 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T737 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
T738 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
S740 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 35254053, 30397120, 23580612, 20305658, 31637018, 34019948, 21740066, 30059200, 35132862, 31492838, 30379171, 32119511, 35289036, 29351928, 29237092
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S78 L78 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S81 L81 Biomuta DOID:4159 / skin cancer [ cosmic ]
S88 F88 Biomuta DOID:1612 / breast cancer [ cosmic ]
S143 I143 Biomuta [ cosmic ]
S147 G147 Biomuta DOID:363 / uterine cancer [ icgc ]
T251 A251 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T259 I259 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S322 N322 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S385 N385 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S442 N442 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S535 P535 Biomuta DOID:1612 / breast cancer [ cosmic ]
T735 A735 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T738 A738 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]