Protein Information

Cytoscape View


UniProt AC / UniProt ID P14859 / PO2F1_HUMAN
Protein Name POU domain, class 2, transcription factor 1
Gene Name Name: POU2F1
Synonyms:OCT1,OTF1;
Organism Homo sapiens (Human)

PRO ID PR:P14859
DAG View
PRO Name POU domain, class 2, transcription factor 1 (human)
Definition A POU domain, class 2, transcription factor 1 that is encoded in the genome of human.
Short Label hPOU2F1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14859 (POU2F1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S81 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S85 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S88 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S92 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
T100 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S141 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S143 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S147 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
T162 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
S167 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 17213819
T226 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus   Signor 17213819, 9368058
S232 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus   Signor 17213819, 9368058
T251 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S269 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
T270 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
T276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S278 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K293 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S335 Phosphorylation Q9HC98 (NEK6) , Q9Y478 (PRKAB1) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   RLIMS-P 21897860, 25937278, 27407111
S366 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S385 Phosphorylation Q13131 (PRKAA1) , P50613 (CDK7) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 1684878, 9368058
T445 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S448 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 17287340, ...23186163
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S78 L78 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:4362 / cervical cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
S85 I85 Biomuta DOID:3571 / liver cancer [ icgc ]
S88 F88 Biomuta DOID:1612 / breast cancer [ cosmic ]
S147 G147 Biomuta DOID:363 / uterine cancer [ tcga ]
T259 I259 Biomuta DOID:363 / uterine cancer [ tcga ]
T276 N276 Biomuta DOID:363 / uterine cancer [ tcga ]
S322 N322 Biomuta DOID:3070 / malignant glioma [ tcga ]
S322 I322 Biomuta DOID:3571 / liver cancer [ icgc ]
S385 N385 Biomuta DOID:1324 / lung cancer [ tcga ]