iPTMnet Report for P14735 (IDE)
Protein Information
UniProt AC / UniProt ID | P14735 / IDE_HUMAN |
Protein Name | Insulin-degrading enzyme |
Gene Name | Name: IDE |
Organism | Homo sapiens (Human) |
PRO ID | PR:P14735 |
PRO Name | insulin-degrading enzyme (human) |
Definition | An insulin-degrading enzyme that is encoded in the genome of human. |
Short Label | hIDE |
Category | organism-gene |
P14735 (IDE) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Ubiquitination | score1 | PRO | ||||
T55 | Phosphorylation | score1 | PhosphoSitePlus | |||
S57 | Phosphorylation | score1 | PhosphoSitePlus | |||
K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
K192 | Acetylation | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
K206 | Acetylation | score1 | PhosphoSitePlus | |||
K206 | Ubiquitination | score1 | PhosphoSitePlus | |||
K212 | Ubiquitination | score1 | PhosphoSitePlus | |||
K217 | Ubiquitination | score1 | PhosphoSitePlus | |||
T220 | Phosphorylation | score1 | PhosphoSitePlus | |||
K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
S276 | Phosphorylation | score1 | PhosphoSitePlus | |||
K281 | Ubiquitination | score1 | PhosphoSitePlus | |||
K299 | Ubiquitination | score1 | PhosphoSitePlus | |||
K308 | Acetylation | score1 | PhosphoSitePlus | |||
K308 | Ubiquitination | score1 | PhosphoSitePlus | |||
K501 | Ubiquitination | score1 | PhosphoSitePlus | |||
K511 | Ubiquitination | score1 | PhosphoSitePlus | |||
K512 | Acetylation | score1 | PhosphoSitePlus | |||
K512 | Ubiquitination | score1 | PhosphoSitePlus | |||
K521 | Acetylation | score1 | PhosphoSitePlus | |||
K527 | Acetylation | score1 | PhosphoSitePlus | |||
K527 | Ubiquitination | score1 | PhosphoSitePlus | |||
K542 | Ubiquitination | score1 | PhosphoSitePlus | |||
K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
K566 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y625 | Phosphorylation | score1 | PhosphoSitePlus | |||
K657 | Ubiquitination | score1 | PhosphoSitePlus | |||
T691 | Phosphorylation | score1 | PhosphoSitePlus | |||
T696 | Phosphorylation | score1 | PhosphoSitePlus | |||
K697 | Ubiquitination | score1 | PhosphoSitePlus | |||
K701 | Ubiquitination | score1 | PhosphoSitePlus | |||
K713 | Ubiquitination | score1 | PhosphoSitePlus | |||
R774 | Methylation | score1 | PhosphoSitePlus | |||
K826 | Ubiquitination | score1 | PhosphoSitePlus | |||
K854 | Ubiquitination | score1 | PhosphoSitePlus | |||
K884 | Ubiquitination | score1 | PhosphoSitePlus | |||
K899 | Acetylation | score1 | PhosphoSitePlus | |||
K899 | Ubiquitination | score1 | PhosphoSitePlus | |||
S901 | Phosphorylation | score1 | PhosphoSitePlus | |||
K929 | Ubiquitination | score1 | PhosphoSitePlus | |||
K933 | Ubiquitination | score1 | PhosphoSitePlus | |||
K938 | Ubiquitination | score1 | PhosphoSitePlus | |||
S955 | Phosphorylation | score1 | PhosphoSitePlus | |||
C974 | Methylation | score1 | IEDB | 31844290 | ||
K1018 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K119 | N119 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K192 | E192 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K223 | R223 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
T268 | S268 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K281 | I281 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K566 | R566 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y625 | C625 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
K938 | T938 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] |