Protein Information

Cytoscape View


UniProt AC / UniProt ID P14735 / IDE_HUMAN
Protein Name Insulin-degrading enzyme
Gene Name Name: IDE
Organism Homo sapiens (Human)

PRO ID PR:P14735
DAG View
PRO Name insulin-degrading enzyme (human)
Definition An insulin-degrading enzyme that is encoded in the genome of human.
Short Label hIDE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14735 (IDE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
T55 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K521 Acetylation PhosphoSitePlus
K527 Acetylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
Y625 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
T691 Phosphorylation PhosphoSitePlus
T696 Phosphorylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
R774 Methylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
K899 Acetylation PhosphoSitePlus
K899 Ubiquitination PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
K929 Ubiquitination PhosphoSitePlus
K933 Ubiquitination PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T55 Phosphorylation HPRD 20068231
T268 Phosphorylation HPRD 20068231
S955 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047941 (hIDE/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K119 N119 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
K192 E192 Biomuta DOID:363 / uterine cancer [ tcga ]
K223 N223 Biomuta DOID:363 / uterine cancer [ tcga ]
T268 S268 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K281 I281 Biomuta DOID:1324 / lung cancer [ tcga ]
K566 R566 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y625 C625 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K657 N657 Biomuta DOID:3571 / liver cancer [ icgc ]
K938 T938 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]