iPTMnet Report for P13671 (C6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13671 / CO6_HUMAN
Protein Name Complement component C6 precursor
Gene Name Name: C6
Organism Homo sapiens (Human)

PRO ID PR:P13671
DAG View
PRO Name complement component C6 (human)
Definition A complement component C6 that is encoded in the genome of human.
Short Label hC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13671 (C6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
W29 C-Glycosylation GlyGen   UniProt 10551839
W32 C-Glycosylation GlyGen   UniProt 10551839
T38 O-Glycosylation GlyGen   UniProt 22267737
S41 Phosphorylation HPRD   PhosphoSitePlus 18452278
S45 Phosphorylation HPRD   PhosphoSitePlus 18452278
N59 N-Glycosylation GlyGen 29391424
W90 C-Glycosylation GlyGen   UniProt 10551839
S278 Phosphorylation HPRD 19007248
S311 Phosphorylation PhosphoSitePlus
N324 N-Glycosylation GlyGen   UniProt 16335952, 24279413, 22267737, ...29391424, 29741879
T392 O-Glycosylation GlyGen   UniProt 22267737
S561 Phosphorylation PhosphoSitePlus
W568 C-Glycosylation GlyGen   UniProt 10551839
W571 C-Glycosylation GlyGen   UniProt 10551839
W574 C-Glycosylation GlyGen   UniProt 10551839
S742 Phosphorylation PhosphoSitePlus
T767 Phosphorylation PhosphoSitePlus
N855 N-Glycosylation GlyGen   UniProt 16335952, 29741879, 29391424
N910 N-Glycosylation GlyGen 29391424
Site PTM Type PTM Enzyme Score Source PMID
N324 N-Glycosylation PRO 24279413


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
W29 * Biomuta DOID:4159 / skin cancer [ cosmic ]
W29 R29 Biomuta DOID:1324 / lung cancer [ cosmic ]
W32 C32 Biomuta DOID:1324 / lung cancer [ cosmic ]
W32 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T38 A38 Biomuta DOID:363 / uterine cancer [ icgc ]
S45 R45 Biomuta DOID:1324 / lung cancer [ cosmic ]
S45 N45 Biomuta DOID:10534 / stomach cancer [ cosmic ]
W90 R90 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
W90 C90 Biomuta DOID:1324 / lung cancer [ cosmic ]
S311 Y311 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S561 F561 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S561 T561 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
W571 S571 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
W571 L571 Biomuta DOID:1324 / lung cancer [ cosmic ]
W571 C571 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S742 T742 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
N855 D855 Biomuta DOID:1319 / brain cancer [ icgc ]