iPTMnet Report for P12830 (CDH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12830 / CADH1_HUMAN
Protein Name Cadherin-1 precursor
Gene Name Name: CDH1
Synonyms:CDHE,UVO;
Organism Homo sapiens (Human)

PRO ID PR:P12830
DAG View
PRO Name cadherin-1 (human)
Definition A cadherin-1 that is encoded in the genome of human.
Short Label hCDH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12830 (CDH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
T217 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T330 Phosphorylation PhosphoSitePlus
T544 O-Glycosylation GlyGen 25813380
N558 N-Glycosylation GlyGen   UniProt 18491227
N570 N-Glycosylation GlyGen   UniProt 18491227
T576 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
N622 N-Glycosylation GlyGen   UniProt 18491227
N637 N-Glycosylation GlyGen   UniProt 18491227
Y663 Phosphorylation PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
T748 Phosphorylation PhosphoSitePlus
Y753 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22252131, 26549256
Y754 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P   UniProt 22252131, 26549256
Y755 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22252131, 26549256
S770 Phosphorylation PhosphoSitePlus   UniProt 24275569
T790 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   RLIMS-P+ 27203386
S793 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y797 Phosphorylation PhosphoSitePlus   RLIMS-P 31286874
S838 Phosphorylation PhosphoSitePlus   RLIMS-P 28163245
S840 Phosphorylation PhosphoSitePlus   RLIMS-P 28163245, 24966173, 35115926
S844 Phosphorylation P48729 (CSNK1A1) , P49674 (CSNK1E) , P48730 (CSNK1D) phospho.ELM   PhosphoSitePlus 17353278
S846 Phosphorylation RLIMS-P 24966173, 35115926
S847 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 24966173, 35115926, 17353278
S850 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 17353278
S851 Phosphorylation phospho.ELM 10671552
S853 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 17353278
K871 Ubiquitination PhosphoSitePlus
Y876 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S838 Phosphorylation P68400 (CSNK2A1) HPRD 10671552
S847 Phosphorylation P49841 (GSK3B) , P68400 (CSNK2A1) HPRD 10671552
S851 Phosphorylation P68400 (CSNK2A1) HPRD 10671552
S853 Phosphorylation P68400 (CSNK2A1) HPRD 10671552


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P12830 (CDH1) S846 P35222 (CTNNB1) decreased_association eFIP 23016862
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) inhibited_association eFIP 22007144
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) inhibited_association eFIP 31829231
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) decreased_association eFIP 25386896
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) decreased_association eFIP 11279024
Phosphorylation P60484 (PTEN) S380 P12830 (CDH1) inhibited_association eFIP 24811168
Phosphorylation Q13309 (SKP2) S72 P12830 (CDH1) increased_association eFIP 31806563
Phosphorylation Q13309 (SKP2) S72 P12830 (CDH1) inhibited_association eFIP 23807222
Phosphorylation Q13309 (SKP2) S64 P12830 (CDH1) inhibited_association eFIP 18239684
Phosphorylation Q96PX1 (RNF157) S663 P12830 (CDH1) unknown eFIP 28655764


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035774 (hCTNNB1/iso:1/Phos:4) Interaction PR:P12830 (hCDH1) PRO 20419129, 21152425
PR:000037185 (hCTNNB1/iso:1/UnPhos:2) Interaction PR:P12830 (hCDH1) PRO 20419129
PR:000037190 (hCTNNB1/iso:1/Phos:7) NOT Interaction PR:P12830 (hCDH1) PRO 21152425
PR:000037194 (hCTNNB1/iso:1/Phos:9) decreased Interaction PR:P12830 (hCDH1) PRO 11279024