iPTMnet Report for P12830 (CDH1)
Protein Information
| UniProt AC / UniProt ID | P12830 / CADH1_HUMAN |
| Protein Name | Cadherin-1 precursor |
| Gene Name | Name: CDH1 Synonyms:CDHE,UVO; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P12830 |
| PRO Name | cadherin-1 (human) |
| Definition | A cadherin-1 that is encoded in the genome of human. |
| Short Label | hCDH1 |
| Category | organism-gene |
DAG ViewP12830 (CDH1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T66 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y68 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S70 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T211 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T217 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T330 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T544 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| N558 | N-Glycosylation | score3 | GlyGen UniProt | 18491227 | ||
| N570 | N-Glycosylation | score3 | GlyGen UniProt | 18491227 | ||
| T576 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T599 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N622 | N-Glycosylation | score3 | GlyGen UniProt | 18491227 | ||
| N637 | N-Glycosylation | score3 | GlyGen UniProt | 18491227 | ||
| Y663 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T748 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y753 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 22252131, 26549256 | ||
| Y754 | Phosphorylation | score4 | IntAct PhosphoSitePlus RLIMS-P UniProt | 22252131, 26549256 | ||
| Y755 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 22252131, 26549256 | ||
| S770 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T790 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P+ | 27203386 | ||
| T790 | Phosphorylation | Q05655 (PRKCD) | score2 | RLIMS-P+ | 27203386 | |
| S793 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| Y797 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31286874 | ||
| S838 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 28163245 | ||
| S840 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 28163245, 24966173, 35115926 | ||
| S844 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 17353278 | ||
| S844 | Phosphorylation | P48729 (CSNK1A1) | score2 | PhosphoSitePlus | 17353278 | |
| S844 | Phosphorylation | P48730 (CSNK1D) | score2 | PhosphoSitePlus | 17353278 | |
| S844 | Phosphorylation | P49674 (CSNK1E) | score2 | PhosphoSitePlus | 17353278 | |
| S846 | Phosphorylation | score1 | RLIMS-P | 24966173, 35115926 | ||
| S847 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 24966173, 35115926, 17353278 | ||
| S847 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 17353278 | |
| S850 | Phosphorylation | score2 | PhosphoSitePlus | 17353278 | ||
| S850 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 17353278 | |
| S851 | Phosphorylation | score2 | phospho.ELM | 10671552 | ||
| S853 | Phosphorylation | score2 | PhosphoSitePlus | 17353278 | ||
| S853 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 17353278 | |
| K871 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y876 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S838 | Phosphorylation | score1 | HPRD | 10671552 | ||
| S838 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 10671552 | |
| S847 | Phosphorylation | score1 | HPRD | 10671552 | ||
| S847 | Phosphorylation | P49841 (GSK3B) | score1 | HPRD | 10671552 | |
| S847 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 10671552 | |
| S851 | Phosphorylation | score1 | HPRD | 10671552 | ||
| S851 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 10671552 | |
| S853 | Phosphorylation | score1 | HPRD | 10671552 | ||
| S853 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 10671552 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P12830 (CDH1) | S846 | P35222 (CTNNB1) | decreased_association | eFIP | 23016862 | |
| Phosphorylation | P35222 (CTNNB1) | Y654 | P12830 (CDH1) | inhibited_association | eFIP | 22007144 | |
| Phosphorylation | P35222 (CTNNB1) | Y654 | P12830 (CDH1) | inhibited_association | eFIP | 31829231 | |
| Phosphorylation | P35222 (CTNNB1) | Y654 | P12830 (CDH1) | decreased_association | eFIP | 25386896 | |
| Phosphorylation | P35222 (CTNNB1) | Y654 | P12830 (CDH1) | decreased_association | eFIP | 11279024 | |
| Phosphorylation | P60484 (PTEN) | S380 | P12830 (CDH1) | inhibited_association | eFIP | 24811168 | |
| Phosphorylation | Q13309 (SKP2) | S72 | P12830 (CDH1) | increased_association | eFIP | 31806563 | |
| Phosphorylation | Q13309 (SKP2) | S72 | P12830 (CDH1) | inhibited_association | eFIP | 23807222 | |
| Phosphorylation | Q13309 (SKP2) | S64 | P12830 (CDH1) | inhibited_association | eFIP | 18239684 | |
| Phosphorylation | Q96PX1 (RNF157) | S663 | P12830 (CDH1) | unknown | eFIP | 28655764 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000035774 (hCTNNB1/iso:1/Phos:4) | Interaction | PR:P12830 (hCDH1) | PRO | 20419129, 21152425 | |
| PR:000037185 (hCTNNB1/iso:1/UnPhos:2) | Interaction | PR:P12830 (hCDH1) | PRO | 20419129 | |
| PR:000037190 (hCTNNB1/iso:1/Phos:7) | NOT Interaction | PR:P12830 (hCDH1) | PRO | 21152425 | |
| PR:000037194 (hCTNNB1/iso:1/Phos:9) | decreased Interaction | PR:P12830 (hCDH1) | PRO | 11279024 |
