iPTMnet Report for P12821 (ACE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12821 / ACE_HUMAN
Protein Name Angiotensin-converting enzyme precursor
Gene Name Name: ACE
Synonyms:DCP,DCP1;
Organism Homo sapiens (Human)

PRO ID PR:P12821
DAG View
PRO Name angiotensin-converting enzyme (human)
Definition An angiotensin-converting enzyme that is encoded in the genome of human.
Short Label hACE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12821 (ACE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N38 N-Glycosylation GlyGen   UniProt 9013598, 20826823
N54 N-Glycosylation GlyGen   UniProt 9013598, 20826823, 16476442
N74 N-Glycosylation GlyGen   UniProt 20826823, 16476442, 26403559
N111 N-Glycosylation GlyGen   UniProt 9013598, 20826823, 19159218
K136 Acetylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
N146 N-Glycosylation GlyGen   UniProt 24190977, 23090970, 16476442, ...9013598, 20826823, 29391424
Y151 Phosphorylation PhosphoSitePlus
N160 N-Glycosylation GlyGen   UniProt 20826823
N318 N-Glycosylation GlyGen   UniProt 16476442
N368 N-Glycosylation GlyGen   UniProt 8626443
T430 Phosphorylation IEDB 32357974
N445 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 23090970, ...29391424, 20826823, 26403559
N509 N-Glycosylation GlyGen   UniProt 16335952, 32125861, 24190977, ...23090970, 16476442, 9013598, 20826823, 29391424, 29741879, 26403559
N523 N-Glycosylation GlyGen 29391424
N617 N-Glycosylation GlyGen   UniProt 8626443
N677 N-Glycosylation GlyGen   UniProt 23056909
N695 N-Glycosylation GlyGen   UniProt 16335952, 9013598, 29391424
T697 Phosphorylation PhosphoSitePlus
N714 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 23056909, 26791533, 29391424, 9013598, 29741879
T716 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
N760 N-Glycosylation GlyGen   UniProt 9013598
R814 Methylation PhosphoSitePlus
S824 Phosphorylation PhosphoSitePlus
R826 Methylation PhosphoSitePlus
N942 N-Glycosylation GlyGen   UniProt 9013598
N1191 N-Glycosylation GlyGen   UniProt 9013598
N1225 N-Glycosylation GlyGen 29391424
S1299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14615289, 21901117, 12386153
S1299 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 12386153
Site PTM Type PTM Enzyme Score Source PMID
N714 N-Glycosylation PRO 26791533
T716 Phosphorylation HPRD 17924679
Site PTM Type PTM Enzyme Score Source PMID
T142 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N74 T74 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N160 S160 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T697 N697 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R814 L814 Biomuta DOID:1324 / lung cancer [ cosmic ]
R826 M826 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]