iPTMnet Report for P12821 (ACE)
Protein Information
UniProt AC / UniProt ID | P12821 / ACE_HUMAN |
Protein Name | Angiotensin-converting enzyme precursor |
Gene Name | Name: ACE Synonyms:DCP,DCP1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P12821 |
PRO Name | angiotensin-converting enzyme (human) |
Definition | An angiotensin-converting enzyme that is encoded in the genome of human. |
Short Label | hACE |
Category | organism-gene |
P12821 (ACE) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
N38 | N-Glycosylation | score2 | UniProt | 9013598 | ||
N54 | N-Glycosylation | score3 | UniProt | 9013598, 16476442 | ||
N74 | N-Glycosylation | score2 | UniProt | 16476442 | ||
N111 | N-Glycosylation | score3 | UniProt | 9013598, 19159218 | ||
K136 | Acetylation | score1 | PhosphoSitePlus | |||
Y140 | Phosphorylation | score1 | PhosphoSitePlus | |||
N146 | N-Glycosylation | score3 | UniProt | 9013598, 16476442 | ||
Y151 | Phosphorylation | score1 | PhosphoSitePlus | |||
N318 | N-Glycosylation | score2 | UniProt | 16476442 | ||
N445 | N-Glycosylation | score1 | UniProt | 19159218 | ||
N509 | N-Glycosylation | score3 | UniProt | 16335952, 9013598, 16476442 | ||
N695 | N-Glycosylation | score3 | UniProt | 16335952, 9013598 | ||
T697 | Phosphorylation | score1 | PhosphoSitePlus | |||
N714 | N-Glycosylation | score3 | UniProt | 16335952, 9013598, 19159218 | ||
T716 | Phosphorylation | score1 | PhosphoSitePlus | |||
K718 | Ubiquitination | score1 | PhosphoSitePlus | |||
N760 | N-Glycosylation | score2 | UniProt | 9013598 | ||
R814 | Methylation | score1 | PhosphoSitePlus | |||
S824 | Phosphorylation | score1 | PhosphoSitePlus | |||
R826 | Methylation | score1 | PhosphoSitePlus | |||
N942 | N-Glycosylation | score2 | UniProt | 9013598 | ||
N1191 | N-Glycosylation | score2 | UniProt | 9013598 | ||
S1299 | Phosphorylation | P68400 (CSNK2A1) | score4 | phospho.ELM PhosphoSitePlus UniProt | 14615289, 12386153 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
N74 | T74 | Biomuta | DOID:1324 / lung cancer [ icgc, tcga ] | |
T697 | N697 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc, tcga ] | |
R826 | M826 | Biomuta | DOID:363 / uterine cancer [ tcga ] |