Protein Information

Cytoscape View

UniProt AC / UniProt ID P12821 / ACE_HUMAN
Protein Name Angiotensin-converting enzyme precursor
Gene Name Name: ACE
Organism Homo sapiens (Human)

PRO ID PR:P12821
DAG View
PRO Name angiotensin-converting enzyme (human)
Definition An angiotensin-converting enzyme that is encoded in the genome of human.
Short Label hACE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P12821 (ACE) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N38 N-Glycosylation UniProt 9013598
N54 N-Glycosylation UniProt 9013598, 16476442
N74 N-Glycosylation UniProt 16476442
N111 N-Glycosylation UniProt 9013598, 19159218
K136 Acetylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
N146 N-Glycosylation UniProt 9013598, 16476442
Y151 Phosphorylation PhosphoSitePlus
N318 N-Glycosylation UniProt 16476442
N445 N-Glycosylation UniProt 19159218
N509 N-Glycosylation UniProt 16335952, 9013598, 16476442
N695 N-Glycosylation UniProt 16335952, 9013598
T697 Phosphorylation PhosphoSitePlus
N714 N-Glycosylation UniProt 16335952, 9013598, 19159218
T716 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
N760 N-Glycosylation UniProt 9013598
R814 Methylation PhosphoSitePlus
S824 Phosphorylation PhosphoSitePlus
R826 Methylation PhosphoSitePlus
N942 N-Glycosylation UniProt 9013598
N1191 N-Glycosylation UniProt 9013598
S1299 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   UniProt 14615289, 12386153
Site PTM Type PTM Enzyme Score Source PMID
T716 Phosphorylation HPRD 17924679
Site PTM Type PTM Enzyme Score Source PMID
T142 Phosphorylation HPRD 17924679

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N74 T74 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
T697 N697 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R826 M826 Biomuta DOID:363 / uterine cancer [ tcga ]