iPTMnet Report for P12318 (FCGR2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12318 / FCG2A_HUMAN
Protein Name Low affinity immunoglobulin gamma Fc region receptor II-a precursor
Gene Name Name: FCGR2A
Synonyms:CD32,FCG2,FCGR2A1,IGFR2;
Organism Homo sapiens (Human)

PRO ID PR:P12318
DAG View
PRO Name low affinity immunoglobulin gamma Fc region receptor II-a (human)
Definition A low affinity immunoglobulin gamma Fc region receptor II-a that is encoded in the genome of human.
Short Label hFCGR2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12318 (FCGR2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N97 N-Glycosylation GlyGen   UniProt 10397151
N178 N-Glycosylation GlyGen   UniProt 10397151
Y240 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation P51451 (BLK) , P43405 (SYK) , P07948 (LYN) , P06241 (FYN) neXtProt   phospho.ELM   PhosphoSitePlus 8756631
T283 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation P07948 (LYN) , P43405 (SYK) , P51451 (BLK) , P06241 (FYN) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 8756631, 7487883
T290 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation P43405 (SYK) , P06241 (FYN) , P07948 (LYN) , P51451 (BLK) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 8756631, 7487883
Site PTM Type PTM Enzyme Score Source PMID
Y280 Phosphorylation P43405 (SYK) , P07948 (LYN) , P51451 (BLK) , P06241 (FYN) HPRD 8756631
Y287 Phosphorylation P06241 (FYN) , P43405 (SYK) , P07948 (LYN) , P51451 (BLK) HPRD 8756631
Y303 Phosphorylation P07948 (LYN) , P43405 (SYK) , P06241 (FYN) , P51451 (BLK) HPRD 8756631


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047387 (hFCGR2A/SigPep-/Phos:1) pY288,pY304 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N178 K178 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K271 N271 Biomuta DOID:363 / uterine cancer [ icgc ]
T277 I277 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T283 A283 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y287 F287 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y288 F288 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]