iPTMnet Report for P12318 (FCGR2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12318 / FCG2A_HUMAN
Protein Name Low affinity immunoglobulin gamma Fc region receptor II-a precursor
Gene Name Name: FCGR2A
Synonyms:CD32,FCG2,FCGR2A1,IGFR2;
Organism Homo sapiens (Human)

PRO ID PR:P12318
DAG View
PRO Name low affinity immunoglobulin gamma Fc region receptor II-a (human)
Definition A low affinity immunoglobulin gamma Fc region receptor II-a that is encoded in the genome of human.
Short Label hFCGR2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12318 (FCGR2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N97 N-Glycosylation GlyGen   UniProt 10397151
N178 N-Glycosylation GlyGen   UniProt 10397151
Y240 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 8756631
Y281 Phosphorylation P06241 (FYN) phospho.ELM 8756631
Y281 Phosphorylation P07948 (LYN) phospho.ELM 8756631
Y281 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus 8756631
Y281 Phosphorylation P51451 (BLK) phospho.ELM 8756631
T283 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 8756631, 7487883
Y288 Phosphorylation P06241 (FYN) phospho.ELM   PhosphoSitePlus 8756631
Y288 Phosphorylation P07948 (LYN) phospho.ELM 8756631
Y288 Phosphorylation P43405 (SYK) phospho.ELM 8756631
Y288 Phosphorylation P51451 (BLK) neXtProt   phospho.ELM   PhosphoSitePlus 8756631
T290 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 8756631, 7487883
Y304 Phosphorylation P06241 (FYN) phospho.ELM 8756631
Y304 Phosphorylation P07948 (LYN) phospho.ELM   PhosphoSitePlus 8756631
Y304 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus 8756631
Y304 Phosphorylation P51451 (BLK) neXtProt   phospho.ELM   PhosphoSitePlus 8756631
Site PTM Type PTM Enzyme Score Source PMID
Y280 Phosphorylation HPRD 8756631
Y280 Phosphorylation P06241 (FYN) HPRD 8756631
Y280 Phosphorylation P07948 (LYN) HPRD 8756631
Y280 Phosphorylation P43405 (SYK) HPRD 8756631
Y280 Phosphorylation P51451 (BLK) HPRD 8756631
Y287 Phosphorylation HPRD 8756631
Y287 Phosphorylation P06241 (FYN) HPRD 8756631
Y287 Phosphorylation P07948 (LYN) HPRD 8756631
Y287 Phosphorylation P43405 (SYK) HPRD 8756631
Y287 Phosphorylation P51451 (BLK) HPRD 8756631
Y303 Phosphorylation HPRD 8756631
Y303 Phosphorylation P06241 (FYN) HPRD 8756631
Y303 Phosphorylation P07948 (LYN) HPRD 8756631
Y303 Phosphorylation P43405 (SYK) HPRD 8756631
Y303 Phosphorylation P51451 (BLK) HPRD 8756631


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047387 (hFCGR2A/SigPep-/Phos:1) pY288,pY304 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N178 K178 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K271 N271 Biomuta DOID:363 / uterine cancer [ icgc ]
T277 I277 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T283 A283 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y287 F287 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y288 F288 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]