iPTMnet Report for P11712 (CYP2C9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11712 / CP2C9_HUMAN
Protein Name Cytochrome P450 2C9
Gene Name Name: CYP2C9
Synonyms:CYP2C10;
Organism Homo sapiens (Human)

PRO ID PR:P11712
DAG View
PRO Name cytochrome P450 2C9 (human)
Definition A cytochrome P450 2C9 that is encoded in the genome of human.
Short Label hCYP2C9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11712 (CYP2C9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S127 F127 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S390 Y390 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S390 F390 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
T392 I392 Biomuta DOID:4159 / skin cancer [ cosmic ]
T392 N392 Biomuta DOID:1319 / brain cancer [ icgc ]
S393 Y393 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S393 F393 Biomuta DOID:4159 / skin cancer [ cosmic ]