iPTMnet Report P10747 CD28

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P10747 / CD28_HUMAN
Protein Name	T-cell-specific surface glycoprotein CD28 precursor
Gene Name	Name: CD28
Organism	Homo sapiens (Human)

PRO ID	PR:P10747 DAG View
PRO Name	T-cell-specific surface glycoprotein CD28 (human)
Definition	A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human.
Short Label	hCD28
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P10747 (CD28) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	N37	N-Glycosylation		score3	GlyGen UniProt	15696168
	C40	Methylation		score1	IEDB	31844290
	C66	Methylation		score1	IEDB	31844290
	N71	N-Glycosylation		score2	GlyGen UniProt	19349973
	N105	N-Glycosylation		score3	GlyGen UniProt	15696168
	N129	N-Glycosylation		score2	GlyGen UniProt	19349973
	K136	Ubiquitination		score1	PhosphoSitePlus
	S189	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332
	Y191	Phosphorylation	P06239 (LCK) , P06241 (FYN) , Q08881 (ITK)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus RLIMS-P+ Signor UniProt	8146197, 22936936, 8183372, ...16094384, 7807015, 10820259, 7584133, 7568038, 8621607, 8992971, 9417079, 19690332
	T195	Phosphorylation		score1	PhosphoSitePlus
	K204	Ubiquitination		score1	PhosphoSitePlus
	Y206	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P	8946678, 8992971, 30197180
	Y209	Phosphorylation	Q08881 (ITK)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	8946678, 22936936, 16094384, ...15144186, 30197180, 8992971, 15592455
	Y218	Phosphorylation	Q08881 (ITK)	score4	phospho.ELM PhosphoSitePlus Signor	8946678, 8992971
	S220	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S189	Phosphorylation		score0	HPRD	19901323
	Y191	Phosphorylation	Q08881 (ITK)	score4	HPRD PRO	19901323, 8992971
	Y206	Phosphorylation	Q08881 (ITK)	score1	HPRD	8992971
	Y209	Phosphorylation	Q08881 (ITK)	score2	HPRD	19901323, 15144186, 8992971
	Y218	Phosphorylation	Q08881 (ITK)	score2	HPRD	15144186, 8992971

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000025790 (hCD28/iso:1/SigPep-/Phos:1)	pY191		PRO	8992971

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y191	C191	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T195	I195	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
T195	A195	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T195	P195	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
S220	P220	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]