iPTMnet Report for P10747 (CD28)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10747 / CD28_HUMAN
Protein Name T-cell-specific surface glycoprotein CD28 precursor
Gene Name Name: CD28
Organism Homo sapiens (Human)

PRO ID PR:P10747
DAG View
PRO Name T-cell-specific surface glycoprotein CD28 (human)
Definition A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human.
Short Label hCD28
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10747 (CD28) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N37 N-Glycosylation GlyGen   UniProt 15696168
C40 Methylation IEDB 31844290
C66 Methylation IEDB 31844290
N71 N-Glycosylation GlyGen   UniProt 19349973
N105 N-Glycosylation GlyGen   UniProt 15696168
N129 N-Glycosylation GlyGen   UniProt 19349973
K136 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y191 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 8146197, 22936936, 8183372, ...16094384, 7807015, 10820259, 7584133, 7568038, 8621607, 8992971, 9417079, 19690332
Y191 Phosphorylation P06239 (LCK) neXtProt   phospho.ELM   Signor 7568038, 22936936, 8992971
Y191 Phosphorylation P06241 (FYN) RLIMS-P+ 7568038
Y191 Phosphorylation Q08881 (ITK) phospho.ELM   Signor 22936936, 8992971
T195 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 8946678, 8992971, 30197180
Y209 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8946678, 22936936, 16094384, ...15144186, 30197180, 8992971, 15592455
Y209 Phosphorylation Q08881 (ITK) phospho.ELM   Signor 22936936, 8992971
Y218 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 8946678, 8992971
Y218 Phosphorylation Q08881 (ITK) phospho.ELM   Signor 8992971
S220 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S189 Phosphorylation HPRD 19901323
Y191 Phosphorylation HPRD   PRO 19901323, 8992971
Y191 Phosphorylation Q08881 (ITK) HPRD 19901323, 8992971
Y206 Phosphorylation HPRD 8992971
Y206 Phosphorylation Q08881 (ITK) HPRD 8992971
Y209 Phosphorylation HPRD 19901323, 15144186, 8992971
Y209 Phosphorylation Q08881 (ITK) HPRD 19901323, 15144186, 8992971
Y218 Phosphorylation HPRD 15144186, 8992971
Y218 Phosphorylation Q08881 (ITK) HPRD 15144186, 8992971


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025790 (hCD28/iso:1/SigPep-/Phos:1) pY191 PRO 8992971


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y191 C191 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T195 I195 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T195 A195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T195 P195 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S220 P220 Biomuta DOID:9256 / colorectal cancer [ cosmic ]