iPTMnet Report for P10721 (KIT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10721 / KIT_HUMAN
Protein Name Mast/stem cell growth factor receptor Kit precursor
Gene Name Name: KIT
Synonyms:SCFR;
Organism Homo sapiens (Human)

PRO ID PR:P10721
DAG View
PRO Name mast/stem cell growth factor receptor Kit (human)
Definition A mast/stem cell growth factor receptor that is encoded in the genome of human.
Short Label hKIT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10721 (KIT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N130 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...17662946, 29741879
N145 N-Glycosylation GlyGen 23090970
K173 Sumoylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
N283 N-Glycosylation GlyGen   UniProt 17662946
N293 N-Glycosylation GlyGen   UniProt 17662946
N300 N-Glycosylation GlyGen   UniProt 17662946
N320 N-Glycosylation GlyGen   UniProt 17662946
N352 N-Glycosylation GlyGen   UniProt 17662946
T354 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
N367 N-Glycosylation GlyGen   UniProt 17662946
N486 N-Glycosylation GlyGen 23090970, 29741879
T488 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
S501 Phosphorylation RLIMS-P 23459373
Y547 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 20147452
Y547 Phosphorylation P10721 (KIT) neXtProt   PhosphoSitePlus   UniProt 20147452
Y553 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 20147452, 10224103
Y553 Phosphorylation P10721 (KIT) neXtProt   PhosphoSitePlus   UniProt 20147452
Y568 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 19265199, 12824176, ...21030588, 12878163, 9038210, 12444928, 9799234, 29482074, 28403213, 16780420, 28915580, 19049823, 18214972, 25717186, 10523831
Y568 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 20147452, 19265199, 12824176, ...9799234, 19049823, 10523831
Y570 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 12824176, 12878163, ...9038210, 9799234, 29482074, 28403213, 28915580, 18214972, 25717186, 10523831
Y570 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 20147452, 9799234, 12824176, ...10523831
Y578 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
T670 Phosphorylation RLIMS-P 30142229
Y703 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 20147452, 19265199, 31857719, ...15007386, 17904548, 10377264, 28403213, 16740725, 30242244, 19049823, 26498480, 31484543, 21887372
Y703 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 20147452, 19265199, 10377264, ...16740725, 19049823, 17904548
T718 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 20147452, 19265199, 7537096, ...15007386, 26893362, 9038210, 19865100, 31824842, 28403213, 28192400, 16740725, 30242244, 19049823, 16570044, 21887372, 1382595
Y721 Phosphorylation P10721 (KIT) neXtProt   PhosphoSitePlus   RLIMS-P+   UniProt 19049823, 20147452, 19265199, ...16740725, 19865100
S729 Phosphorylation PhosphoSitePlus
Y730 Phosphorylation neXtProt   PRO   PhosphoSitePlus   UniProt 20147452
Y730 Phosphorylation P10721 (KIT) neXtProt   UniProt 20147452
K735 Ubiquitination PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
S741 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 7539802
S741 Phosphorylation P17252 (PRKCA) neXtProt   PhosphoSitePlus   Signor 7539802
S746 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17156394, 7539802
S746 Phosphorylation P17252 (PRKCA) neXtProt   PhosphoSitePlus   Signor 7539802
Y747 Phosphorylation PhosphoSitePlus
T801 Phosphorylation PhosphoSitePlus
S821 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 7539802
Y823 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 23803604, 12824176, ...32530065, 24465823, 19049823, 26498480
Y823 Phosphorylation P10721 (KIT) neXtProt   PhosphoSitePlus   Signor   UniProt 19049823, 20147452, 12824176
S891 Phosphorylation PhosphoSitePlus   UniProt 12878163
Y900 Phosphorylation IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 12878163
Y900 Phosphorylation P10721 (KIT) UniProt 12878163
Y900 Phosphorylation P12931 (SRC) phospho.ELM   Signor 12878163
S931 Phosphorylation PhosphoSitePlus
Y936 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10377264, 19265199, 7537096, ...21887372, 12444928, 24465823, 18083107, 28403213, 16780420, 19049823, 17904548
Y936 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10377264, 19049823, 17904548, ...19265199
S937 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S959 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 7539802
Site PTM Type PTM Enzyme Score Source PMID
N130 N-Glycosylation PRO 29671580
T354 Phosphorylation HPRD 18491316
Y362 Phosphorylation HPRD 18491316
Y545 Phosphorylation HPRD 9528781
Y547 Phosphorylation HPRD 9528781
Y553 Phosphorylation HPRD 9528781
Y568 Phosphorylation HPRD 9799234
Y568 Phosphorylation P10721 (KIT) HPRD 9799234
Y570 Phosphorylation HPRD 9799234
Y570 Phosphorylation P10721 (KIT) HPRD 9799234
Y703 Phosphorylation HPRD 10377264
Y703 Phosphorylation P10721 (KIT) HPRD 10377264
Y721 Phosphorylation HPRD 9038210
Y730 Phosphorylation HPRD 7509796
S741 Phosphorylation HPRD 7539802
S741 Phosphorylation P17252 (PRKCA) HPRD 7539802
S746 Phosphorylation HPRD 7539802
S746 Phosphorylation P17252 (PRKCA) HPRD 7539802
Y747 Phosphorylation HPRD 7509796
S821 Phosphorylation HPRD 7539802
S821 Phosphorylation P17252 (PRKCA) HPRD 7539802
Y900 Phosphorylation HPRD 12878163
Y900 Phosphorylation P12931 (SRC) HPRD 12878163
Y936 Phosphorylation HPRD 10377264
Y936 Phosphorylation P10721 (KIT) HPRD 10377264
S959 Phosphorylation HPRD 7539802
S959 Phosphorylation P17252 (PRKCA) HPRD 7539802
Site PTM Type PTM Enzyme Score Source PMID
T354 Phosphorylation HPRD 18491316
Y362 Phosphorylation HPRD 18491316
Y932 Phosphorylation HPRD 18083107


P10721 (KIT) as PTM Enzyme



Substrate Site Score Source PMID
P10721 (KIT) Y547 neXtProt   PhosphoSitePlus   UniProt 20147452
P10721 (KIT) Y553 neXtProt   PhosphoSitePlus   UniProt 20147452
P10721 (KIT) Y568 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 20147452, 19265199, 12824176, ...9799234, 19049823, 10523831
P10721 (KIT) Y570 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 20147452, 9799234, 12824176, ...10523831
P10721 (KIT) Y703 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 20147452, 19265199, 10377264, ...16740725, 19049823, 17904548
P10721 (KIT) Y721 neXtProt   PhosphoSitePlus   RLIMS-P+   UniProt 19049823, 20147452, 19265199, ...16740725, 19865100
P10721 (KIT) Y730 neXtProt   UniProt 20147452
P10721 (KIT) Y823 neXtProt   PhosphoSitePlus   Signor   UniProt 19049823, 20147452, 12824176
P10721 (KIT) Y900 UniProt 12878163
P10721 (KIT) Y936 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10377264, 19049823, 17904548, ...19265199
P42224-1 (STAT1) Y701 HPRD 9355737
Q9GZY6 (LAT2) Y110 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y118 PhosphoSitePlus 17993265


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048128 (hKIT/SigPep-/Phos:1) pS741,pS746 PRO
PR:000048129 (hKIT/SigPep-/Phos:2) pY568,pY570,pY703,pY721,pY730,pY823,pY900,pY936 PRO
PR:000048130 (hKIT/SigPep-/Phos:3) pY568,pY570,pY703,pY721,pY730,pY823,pY936 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10721 (KIT) Y900 Q8IZL9 (CDK20) unknown eFIP 12878163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N130 D130 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S217 P217 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T232 M232 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S240 T240 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S241 Y241 Biomuta DOID:363 / uterine cancer [ icgc ]
N283 I283 Biomuta DOID:4159 / skin cancer [ cosmic ]
N293 T293 Biomuta DOID:4159 / skin cancer [ cosmic ]
N293 S293 Biomuta DOID:1324 / lung cancer [ cosmic ]
N293 K293 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y362 H362 Biomuta DOID:3565 / meningioma [ cosmic ]
Y362 C362 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N486 I486 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
N486 D486 Biomuta DOID:184 / bone cancer [ cosmic ]
Y494 C494 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y545 H545 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y547 N547 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y553 N553 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ]
Y553 C553 Biomuta [ cosmic ]
Y553 S553 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y553 V553 Biomuta [ cosmic ]
Y568 S568 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ icgc ]
Y568 D568 Biomuta [ cosmic ]
Y568 C568 Biomuta [ cosmic ]
Y570 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
Y570 D570 Biomuta [ cosmic ]
Y578 C578 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y578 S578 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K642 Q642 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ]
K642 E642 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ civic ] DOID:3277 / thymus cancer [ cosmic ] DOID:4159 / skin cancer [ civic, cosmic, icgc, tcga ]
K642 N642 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T670 I670 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ civic ]
T670 E670 Biomuta [ cosmic ]
T670 S670 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y703 H703 Biomuta DOID:1324 / lung cancer [ cosmic ]
T718 S718 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y721 H721 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S729 Y729 Biomuta DOID:363 / uterine cancer [ cosmic ]
S729 F729 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K735 E735 Biomuta DOID:3571 / liver cancer [ cosmic ]
S741 Y741 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T801 N801 Biomuta DOID:3571 / liver cancer [ cosmic ]
T801 I801 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ]
T801 A801 Biomuta DOID:4362 / cervical cancer [ icgc ]
S821 Y821 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y823 C823 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y823 D823 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ civic ] DOID:2998 / testicular cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y823 H823 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y823 N823 Biomuta DOID:2998 / testicular cancer [ cosmic ]
S931 I931 Biomuta DOID:10534 / stomach cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ]