Protein Information

Cytoscape View


UniProt AC / UniProt ID P10721 / KIT_HUMAN
Protein Name Mast/stem cell growth factor receptor Kit precursor
Gene Name Name: KIT
Synonyms:SCFR;
Organism Homo sapiens (Human)

PRO ID PR:P10721
DAG View
PRO Name mast/stem cell growth factor receptor Kit (human)
Definition A mast/stem cell growth factor receptor that is encoded in the genome of human.
Short Label hKIT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10721 (KIT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N130 N-Glycosylation UniProt 16335952, 17662946
K173 Sumoylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
N283 N-Glycosylation UniProt 17662946
N293 N-Glycosylation UniProt 17662946
N300 N-Glycosylation UniProt 17662946
N320 N-Glycosylation UniProt 17662946
N352 N-Glycosylation UniProt 17662946
T354 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
N367 N-Glycosylation UniProt 17662946
T488 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
Y547 Phosphorylation P10721 (KIT) neXtProt   PhosphoSitePlus   UniProt 20147452
Y553 Phosphorylation P10721 (KIT) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 20147452, 10224103
Y568 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 19265199, 21030588, ...12878163, 9038210, 9799234, 12824176, 16780420, 19049823, 25717186, 10523831
Y570 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 12878163, 9038210, ...12824176, 9799234, 25717186, 10523831
Y578 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
Y703 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 19265199, 21887372, ...10377264, 16740725, 19049823, 26498480, 17904548
T718 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 11520784, 19265199, 20147452, ...21887372, 9038210, 19865100, 16740725, 26893362, 19049823, 16570044
S729 Phosphorylation PhosphoSitePlus
Y730 Phosphorylation P10721 (KIT) neXtProt   PRO   PhosphoSitePlus   UniProt 20147452
K735 Ubiquitination PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
S741 Phosphorylation P17252 (PRKCA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 7539802
S746 Phosphorylation P17252 (PRKCA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 7539802
Y747 Phosphorylation PhosphoSitePlus
T801 Phosphorylation PhosphoSitePlus
S821 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 7539802
Y823 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 23803604, 12824176, ...19049823, 26498480
S891 Phosphorylation PhosphoSitePlus   UniProt 12878163
Y900 Phosphorylation P12931 (SRC) , P10721 (KIT) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20147452, 12878163
S931 Phosphorylation PhosphoSitePlus
Y936 Phosphorylation P10721 (KIT) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18083107, 19265199, 21887372, ...10377264, 16780420, 19049823, 17904548
S937 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S959 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 7539802
Site PTM Type PTM Enzyme Score Source PMID
T354 Phosphorylation HPRD 18491316
Y362 Phosphorylation HPRD 18491316
Y545 Phosphorylation HPRD 9528781
Y547 Phosphorylation HPRD 9528781
Y553 Phosphorylation HPRD 9528781
Y568 Phosphorylation P10721 (KIT) HPRD 9799234
Y570 Phosphorylation P10721 (KIT) HPRD 9799234
Y703 Phosphorylation P10721 (KIT) HPRD 10377264
Y721 Phosphorylation HPRD 9038210
Y730 Phosphorylation HPRD 7509796
S741 Phosphorylation P17252 (PRKCA) HPRD 7539802
S746 Phosphorylation P17252 (PRKCA) HPRD 7539802
Y747 Phosphorylation HPRD 7509796
S821 Phosphorylation P17252 (PRKCA) HPRD 7539802
Y900 Phosphorylation P12931 (SRC) HPRD 12878163
Y936 Phosphorylation P10721 (KIT) HPRD 10377264
S959 Phosphorylation P17252 (PRKCA) HPRD 7539802
Site PTM Type PTM Enzyme Score Source PMID
T354 Phosphorylation HPRD 18491316
Y362 Phosphorylation HPRD 18491316
Y932 Phosphorylation HPRD 18083107


P10721 (KIT) as PTM Enzyme



Substrate Site Score Source PMID
P10721 (KIT) Y547 neXtProt   PhosphoSitePlus   UniProt 20147452
P10721 (KIT) Y553 neXtProt   PhosphoSitePlus   UniProt 20147452
P10721 (KIT) Y568 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 20147452, 19265199, 12824176, ...9799234, 19049823, 10523831
P10721 (KIT) Y570 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12824176, 9799234, 10523831, ...20147452
P10721 (KIT) Y703 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10377264, 19049823, 17904548, ...19265199, 20147452
P10721 (KIT) Y721 neXtProt   PhosphoSitePlus   UniProt 19049823, 20147452, 19265199, ...19865100
P10721 (KIT) Y730 neXtProt   UniProt 20147452
P10721 (KIT) Y823 neXtProt   PhosphoSitePlus   Signor   UniProt 19049823, 20147452, 12824176
P10721 (KIT) Y900 UniProt 12878163
P10721 (KIT) Y936 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10377264, 19049823, 17904548, ...19265199
P42224-1 (STAT1) Y701 HPRD 9355737
Q9GZY6 (LAT2) Y110 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y118 PhosphoSitePlus 17993265


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048128 (hKIT/SigPep-/Phos:1) pS741,pS746 PRO
PR:000048129 (hKIT/SigPep-/Phos:2) pY568,pY570,pY703,pY721,pY730,pY823,pY900,pY936 PRO
PR:000048130 (hKIT/SigPep-/Phos:3) pY568,pY570,pY703,pY721,pY730,pY823,pY936 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10721 (KIT) Y900 Q8IZL9 (CDK20) unknown eFIP 12878163