iPTMnet Report for P08648 (ITGA5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08648 / ITA5_HUMAN
Protein Name Integrin alpha-5 precursor
Gene Name Name: ITGA5
Synonyms:FNRA;
Organism Homo sapiens (Human)

PRO ID PR:P08648
DAG View
PRO Name integrin alpha-5 (human)
Definition An integrin alpha-5 that is encoded in the genome of human.
Short Label hITGA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08648 (ITGA5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N84 N-Glycosylation GlyGen   UniProt 22451694, 33962943
S123 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus   UniProt 24275569
S128 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
C176 Methylation IEDB 31844290
N182 N-Glycosylation GlyGen   UniProt 29741879, 22451694, 33962943
S210 Phosphorylation PhosphoSitePlus
N297 N-Glycosylation GlyGen   UniProt 19349973, 22451694, 19159218, ...29391424, 33962943
N307 N-Glycosylation GlyGen   UniProt 22451694, 19349973, 19159218, ...33962943
N316 N-Glycosylation GlyGen   UniProt 22451694, 33962943
S394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
S494 Phosphorylation IEDB 35494241
N518 N-Glycosylation GlyGen 29391424
N524 N-Glycosylation GlyGen   UniProt 33962943
N609 N-Glycosylation GlyGen   UniProt 22451694, 33962943
N675 N-Glycosylation GlyGen   UniProt 29391424, 19159218
N712 N-Glycosylation GlyGen 27641064
C731 S-Nitrosylation dbSNO 25040305
S742 Phosphorylation PhosphoSitePlus
N773 N-Glycosylation GlyGen   UniProt 23090970, 19349973, 19159218, ...29391424, 24190977
N868 N-Glycosylation GlyGen 23090970, 29741879, 15702487, ...29391424, 24190977
S887 Phosphorylation PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
S1047 O-Glycosylation GlyGen 33214551, 28510447, 34019948, ...31202709, 35254053
S1047 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N868 N-Glycosylation PRO 15702487


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S124 L124 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S126 P126 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K137 E137 Biomuta DOID:3571 / liver cancer [ cosmic ]
S395 P395 Biomuta DOID:3571 / liver cancer [ cosmic ]
S395 F395 Biomuta DOID:1115 / sarcoma [ icgc ]
N524 S524 Biomuta DOID:1324 / lung cancer [ cosmic ]
N609 Y609 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S887 P887 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K943 N943 Biomuta DOID:1324 / lung cancer [ cosmic ]