Protein Information

Cytoscape View

UniProt AC / UniProt ID P08648 / ITA5_HUMAN
Protein Name Integrin alpha-5 precursor
Gene Name Name: ITGA5
Organism Homo sapiens (Human)

PRO ID PR:P08648
DAG View
PRO Name integrin alpha-5 (human)
Definition An integrin alpha-5 that is encoded in the genome of human.
Short Label hITGA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P08648 (ITGA5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N84 N-Glycosylation GlyGen   UniProt 22451694
S123 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus   UniProt 24275569
S128 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
N182 N-Glycosylation GlyGen   UniProt 29741879, 22451694
S210 Phosphorylation PhosphoSitePlus
N297 N-Glycosylation GlyGen   UniProt 22451694, 29391424, 19159218, ...19349973
N307 N-Glycosylation GlyGen   UniProt 22451694, 19159218, 19349973
N316 N-Glycosylation GlyGen   UniProt 22451694
S394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
N518 N-Glycosylation GlyGen 29391424
N609 N-Glycosylation GlyGen   UniProt 22451694
N675 N-Glycosylation GlyGen   UniProt 29391424, 19159218
C731 S-Nitrosylation dbSNO 25040305
S742 Phosphorylation PhosphoSitePlus
N773 N-Glycosylation GlyGen   UniProt 23090970, 24190977, 29391424, ...19159218, 19349973
N868 N-Glycosylation GlyGen 23090970, 29741879, 15702487, ...29391424, 24190977
S887 Phosphorylation PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S126 P126 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K137 E137 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S395 F395 Biomuta DOID:1115 / sarcoma [ icgc, tcga ]
Y487 C487 Biomuta DOID:10534 / stomach cancer [ tcga ]
N609 Y609 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
N868 K868 Biomuta DOID:3571 / liver cancer [ icgc ]
S887 P887 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K943 N943 Biomuta DOID:1324 / lung cancer [ cosmic ]