iPTMnet Report for P08567 (PLEK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08567 / PLEK_HUMAN
Protein Name Pleckstrin
Gene Name Name: PLEK
Synonyms:P47;
Organism Homo sapiens (Human)

PRO ID PR:P08567
DAG View
PRO Name pleckstrin (human)
Definition A pleckstrin that is encoded in the genome of human.
Short Label hPLEK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08567 (PLEK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Acetylation PhosphoSitePlus
C59 Methylation IEDB 31844290
K64 Acetylation PhosphoSitePlus   UniProt 19608861
S113 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9060471, 8615792, 7559487
S113 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 8615792, 7559487
T114 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 9060471, 7559487
S117 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9060471, 20058876, 18452278, ...19367720, 8615792, 7559487
S117 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 8615792, 7559487
T123 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation HPRD   PhosphoSitePlus 18452278
S132 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S183 Phosphorylation HPRD   PhosphoSitePlus 17924679
S197 Phosphorylation HPRD   PhosphoSitePlus 17924679
C250 Methylation IEDB 31844290
Y277 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
C295 Methylation IEDB 31844290
S299 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation RLIMS-P 23569086


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 Y113 Biomuta [ cosmic ]
T114 S114 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T114 I114 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S117 C117 Biomuta DOID:1324 / lung cancer [ cosmic ]
S132 A132 Biomuta DOID:1324 / lung cancer [ cosmic ]
T136 N136 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S183 L183 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y278 N278 Biomuta DOID:363 / uterine cancer [ cosmic ]
S302 I302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S304 L304 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S304 T304 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]