Protein Information

Cytoscape View

UniProt AC / UniProt ID P08567 / PLEK_HUMAN
Protein Name Pleckstrin
Gene Name Name: PLEK
Organism Homo sapiens (Human)

PRO ID PR:P08567
DAG View
PRO Name pleckstrin (human)
Definition A pleckstrin that is encoded in the genome of human.
Short Label hPLEK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P08567 (PLEK) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K51 Acetylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus   UniProt 19608861
S113 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10995449, 9060471, 8615792, ...7559487
T114 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 10995449, 9060471, 7559487
S117 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9060471, 20058876, 18452278, ...19367720, 10995449, 8615792, 7559487
T123 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation HPRD   PhosphoSitePlus 18452278
S132 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S183 Phosphorylation HPRD   PhosphoSitePlus 17924679
S197 Phosphorylation HPRD   PhosphoSitePlus 17924679
Y277 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation RLIMS-P 23569086

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T114 S114 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S132 A132 Biomuta DOID:1324 / lung cancer [ cosmic ]
T136 N136 Biomuta DOID:1324 / lung cancer [ tcga ]
S183 L183 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ]
Y278 N278 Biomuta DOID:363 / uterine cancer [ cosmic ]
S302 I302 Biomuta DOID:3571 / liver cancer [ icgc ]
S304 L304 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]