iPTMnet Report for P07550 (ADRB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07550 / ADRB2_HUMAN
Protein Name Beta-2 adrenergic receptor
Gene Name Name: ADRB2
Synonyms:ADRB2R,B2AR;
Organism Homo sapiens (Human)

PRO ID PR:P07550
DAG View
PRO Name beta-2 adrenergic receptor (human)
Definition A beta-2 adrenergic receptor that is encoded in the genome of human.
Short Label hADRB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07550 (ADRB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
N6 N-Glycosylation GlyGen 28467637
N15 N-Glycosylation GlyGen 28467637
T68 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation P08069 (IGF1R) , P06213 (INSR) HPRD   phospho.ELM   PhosphoSitePlus 8557631, 8910597
Y141 Phosphorylation P06213 (INSR) , P08069 (IGF1R) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8557631, 8521811, 8910597
T146 O-Glycosylation GlyGen 31492838
N187 N-Glycosylation GlyGen 28467637
Y219 Phosphorylation PhosphoSitePlus
S246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18578522
S261 Phosphorylation Q05655 (PRKCD) HPRD   PhosphoSitePlus   RLIMS-P 1848190, 27646272, 24677713, ...27481942
S262 Phosphorylation Q05655 (PRKCD) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 27481942, 1848190, 27646272, ...14722251, 8083204, 24690384, 21225244, 24677713, 11146000
Y308 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 12436935, 7559596
S345 Phosphorylation P31749 (AKT1) , P17612 (PRKACA) , Q05655 (PRKCD) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24003153, 1848190, 27646272, ...11809767, 8083204, 24690384, 11146000
S346 Phosphorylation P17612 (PRKACA) , Q05655 (PRKCD) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24003153, 1848190, 27646272, ...11809767, 8083204, 24690384, 11146000
Y350 Phosphorylation P06213 (INSR) HPRD   IntAct   PhosphoSitePlus   RLIMS-P 9830057, 8557631, 26608913, ...19864009
Y354 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 8557631
S355 Phosphorylation P43250 (GRK6) , P35626 (GRK3) , P25098 (GRK2) , P34947 (GRK5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 25770216, 16980556, 21868357, ...14722251, 20038610, 18034461, 24690384, 24677713, 18056263
S356 Phosphorylation P43250 (GRK6) , P25098 (GRK2) , P35626 (GRK3) , P34947 (GRK5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 25770216, 16980556, 21868357, ...14722251, 20038610, 18034461, 24690384, 24677713, 18056263
T360 Phosphorylation PhosphoSitePlus   RLIMS-P 29335412
S364 Phosphorylation HPRD   PhosphoSitePlus 8557631
T384 Phosphorylation P25098 (GRK2) , P34947 (GRK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852
T393 Phosphorylation P34947 (GRK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 9516468, 8662852
S396 Phosphorylation P25098 (GRK2) , P34947 (GRK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852, 21868357
S401 Phosphorylation P25098 (GRK2) , P34947 (GRK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852
S407 Phosphorylation P34947 (GRK5) , P25098 (GRK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852, 21868357
T408 Phosphorylation PhosphoSitePlus
S411 Phosphorylation P25098 (GRK2) , P34947 (GRK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 9516468, 8662852, 21868357


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046277 (hADRB2/PhosSer+) p PRO
PR:000046278 (hADRB2/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic ]
S262 F262 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S345 Y345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S355 F355 Biomuta [ cosmic ]
T393 N393 Biomuta DOID:363 / uterine cancer [ icgc ]
S396 G396 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S396 R396 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S407 N407 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]