iPTMnet Report for P07550 (ADRB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07550 / ADRB2_HUMAN
Protein Name Beta-2 adrenergic receptor
Gene Name Name: ADRB2
Synonyms:ADRB2R,B2AR;
Organism Homo sapiens (Human)

PRO ID PR:P07550
DAG View
PRO Name beta-2 adrenergic receptor (human)
Definition A beta-2 adrenergic receptor that is encoded in the genome of human.
Short Label hADRB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07550 (ADRB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
N6 N-Glycosylation GlyGen 28467637
N15 N-Glycosylation GlyGen 28467637
T68 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8557631, 8910597
Y132 Phosphorylation P06213 (INSR) HPRD 8557631
Y132 Phosphorylation P08069 (IGF1R) phospho.ELM 8910597
Y141 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8557631, 8521811, 8910597
Y141 Phosphorylation P06213 (INSR) HPRD 8557631
Y141 Phosphorylation P08069 (IGF1R) phospho.ELM 8910597
T146 O-Glycosylation GlyGen 31492838
N187 N-Glycosylation GlyGen 28467637
Y219 Phosphorylation PhosphoSitePlus
S246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18578522
S261 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 1848190, 27646272, 24677713, ...27481942
S261 Phosphorylation Q05655 (PRKCD) HPRD 1848190
S262 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 27481942, 1848190, 27646272, ...14722251, 8083204, 24690384, 21225244, 24677713, 11146000
S262 Phosphorylation Q05655 (PRKCD) HPRD 1848190
Y308 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 12436935, 7559596
S345 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24003153, 1848190, 27646272, ...11809767, 8083204, 24690384, 11146000
S345 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 24003153
S345 Phosphorylation P31749 (AKT1) Signor 11809767
S345 Phosphorylation Q05655 (PRKCD) HPRD 1848190
S346 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24003153, 1848190, 27646272, ...11809767, 8083204, 24690384, 11146000
S346 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 24003153
S346 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 11809767
S346 Phosphorylation Q05655 (PRKCD) HPRD 1848190
Y350 Phosphorylation HPRD   IntAct   PhosphoSitePlus   RLIMS-P 9830057, 8557631, 26608913, ...19864009
Y350 Phosphorylation P06213 (INSR) HPRD 8557631
Y354 Phosphorylation HPRD   PhosphoSitePlus 8557631
Y354 Phosphorylation P06213 (INSR) HPRD 8557631
S355 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 25770216, 16980556, 21868357, ...14722251, 20038610, 18034461, 24690384, 24677713, 18056263
S355 Phosphorylation P25098 (GRK2) PhosphoSitePlus 14722251
S355 Phosphorylation P34947 (GRK5) neXtProt   PhosphoSitePlus 20038610, 25770216, 18034461, ...14722251
S355 Phosphorylation P35626 (GRK3) PhosphoSitePlus 25770216
S355 Phosphorylation P43250 (GRK6) PhosphoSitePlus 25770216, 21868357
S356 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 25770216, 16980556, 21868357, ...14722251, 20038610, 18034461, 24690384, 24677713, 18056263
S356 Phosphorylation P25098 (GRK2) PhosphoSitePlus 14722251
S356 Phosphorylation P34947 (GRK5) neXtProt   PhosphoSitePlus 20038610, 25770216, 18034461, ...14722251
S356 Phosphorylation P35626 (GRK3) PhosphoSitePlus 25770216
S356 Phosphorylation P43250 (GRK6) PhosphoSitePlus 25770216, 21868357
T360 Phosphorylation PhosphoSitePlus   RLIMS-P 29335412
S364 Phosphorylation HPRD   PhosphoSitePlus 8557631
T384 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852
T384 Phosphorylation P25098 (GRK2) PhosphoSitePlus 8662852
T384 Phosphorylation P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 8662852
T393 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 9516468, 8662852
T393 Phosphorylation P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 8662852
S396 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852, 21868357
S396 Phosphorylation P25098 (GRK2) PhosphoSitePlus 8662852, 21868357
S396 Phosphorylation P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 8662852
S401 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852
S401 Phosphorylation P25098 (GRK2) PhosphoSitePlus 8662852
S401 Phosphorylation P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 8662852
S407 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662852, 21868357
S407 Phosphorylation P25098 (GRK2) PhosphoSitePlus 8662852, 21868357
S407 Phosphorylation P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 8662852
T408 Phosphorylation PhosphoSitePlus
S411 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 9516468, 8662852, 21868357
S411 Phosphorylation P25098 (GRK2) PhosphoSitePlus 21868357
S411 Phosphorylation P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 8662852


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046277 (hADRB2/PhosSer+) p PRO
PR:000046278 (hADRB2/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic ]
S262 F262 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S345 Y345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S355 F355 Biomuta [ cosmic ]
T393 N393 Biomuta DOID:363 / uterine cancer [ icgc ]
S396 G396 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S396 R396 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S407 N407 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]