iPTMnet Report for P07384 (CAPN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07384 / CAN1_HUMAN
Protein Name Calpain-1 catalytic subunit
Gene Name Name: CAPN1
Synonyms:CANPL1;ORFNames:PIG30;
Organism Homo sapiens (Human)

PRO ID PR:P07384
DAG View
PRO Name calpain-1 catalytic subunit (human)
Definition A calpain-1 catalytic subunit that is encoded in the genome of human.
Short Label hCAPN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07384 (CAPN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895
S2 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S77 Phosphorylation phospho.ELM 12843408
S78 Phosphorylation phospho.ELM 12843408
K79 Ubiquitination PhosphoSitePlus
T80 Phosphorylation phospho.ELM 12843408
Y81 Phosphorylation phospho.ELM 12843408
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
Y195 Phosphorylation IEDB 35494241
K229 Methylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus   UniProt 23186163
K359 Ubiquitination PhosphoSitePlus
S360 Phosphorylation phospho.ELM 12843408
T362 Phosphorylation phospho.ELM 12843408
K365 Ubiquitination PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
S379 Phosphorylation phospho.ELM   PhosphoSitePlus 12843408
T380 Phosphorylation phospho.ELM 12843408
Y387 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
Y410 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation phospho.ELM 12843408
K461 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S256 G256 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T404 M404 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K461 Q461 Biomuta DOID:1319 / brain cancer [ icgc ]
S474 V474 Biomuta DOID:4159 / skin cancer [ cosmic ]
S474 L474 Biomuta DOID:1324 / lung cancer [ cosmic ]
S622 F622 Biomuta DOID:4159 / skin cancer [ cosmic ]