iPTMnet Report for P07384 (CAPN1)
Protein Information
UniProt AC / UniProt ID | P07384 / CAN1_HUMAN |
Protein Name | Calpain-1 catalytic subunit |
Gene Name | Name: CAPN1 Synonyms:CANPL1;ORFNames:PIG30; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P07384 |
PRO Name | calpain-1 catalytic subunit (human) |
Definition | A calpain-1 catalytic subunit that is encoded in the genome of human. |
Short Label | hCAPN1 |
Category | organism-gene |
P07384 (CAPN1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 19413330, 22814378, 22223895 | ||
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y42 | Phosphorylation | score1 | PhosphoSitePlus | |||
K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
S77 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
S78 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
K79 | Ubiquitination | score1 | PhosphoSitePlus | |||
T80 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
Y81 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
K84 | Acetylation | score1 | PhosphoSitePlus | |||
K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
S93 | Phosphorylation | score1 | PhosphoSitePlus | |||
K193 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y195 | Phosphorylation | score1 | IEDB | 35494241 | ||
K229 | Methylation | score1 | PhosphoSitePlus | |||
K229 | Ubiquitination | score1 | PhosphoSitePlus | |||
S232 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y235 | Phosphorylation | score1 | PhosphoSitePlus | |||
K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
S251 | Phosphorylation | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score1 | PhosphoSitePlus | |||
S256 | Phosphorylation | score1 | PhosphoSitePlus | |||
K270 | Ubiquitination | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
S290 | Phosphorylation | score1 | PhosphoSitePlus | |||
K328 | Ubiquitination | score1 | PhosphoSitePlus | |||
T354 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K359 | Ubiquitination | score1 | PhosphoSitePlus | |||
S360 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
T362 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
K365 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y371 | Phosphorylation | score1 | PhosphoSitePlus | |||
T374 | Phosphorylation | score1 | PhosphoSitePlus | |||
S379 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 12843408 | ||
T380 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
Y387 | Phosphorylation | score1 | PhosphoSitePlus | |||
K398 | Ubiquitination | score1 | PhosphoSitePlus | |||
T404 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y410 | Phosphorylation | score1 | PhosphoSitePlus | |||
S415 | Phosphorylation | score1 | PhosphoSitePlus | |||
S418 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y446 | Phosphorylation | score2 | phospho.ELM | 12843408 | ||
K461 | Ubiquitination | score1 | PhosphoSitePlus | |||
S470 | Phosphorylation | score1 | PhosphoSitePlus | |||
S474 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y494 | Phosphorylation | score1 | PhosphoSitePlus | |||
K505 | Ubiquitination | score1 | PhosphoSitePlus | |||
S539 | Phosphorylation | score1 | PhosphoSitePlus | |||
K564 | Ubiquitination | score1 | PhosphoSitePlus | |||
K583 | Ubiquitination | score1 | PhosphoSitePlus | |||
S622 | Phosphorylation | score1 | PhosphoSitePlus | |||
S636 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S256 | G256 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
T404 | M404 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K461 | Q461 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
S474 | V474 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S474 | L474 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S622 | F622 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |