Protein Information

Cytoscape View


UniProt AC / UniProt ID P07332 / FES_HUMAN
Protein Name Tyrosine-protein kinase Fes/Fps
Gene Name Name: FES
Synonyms:FPS;
Organism Homo sapiens (Human)

PRO ID PR:P07332
DAG View
PRO Name tyrosine-protein kinase Fes/Fps (human)
Definition A tyrosine-protein kinase Fes/Fps that is encoded in the genome of human.
Short Label hFES
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07332 (FES) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S64 Phosphorylation PhosphoSitePlus   UniProt 19369195
S67 Phosphorylation PhosphoSitePlus   UniProt 19369195
S100 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus   UniProt 19369195
S373 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus   UniProt 24275569
T409 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus   UniProt 24275569
S412 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus   UniProt 20111072
T423 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
Y614 Phosphorylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
Y713 Phosphorylation P07332 (FES) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 19382747, 8334128, ...8955135, 7687763, 8663427, 15485904, 18775312, 18046454
S716 Phosphorylation PhosphoSitePlus   UniProt 19369195
K725 Ubiquitination PhosphoSitePlus
Y734 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
Y811 Phosphorylation P07332 (FES) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7687763, 8663427
Site PTM Type PTM Enzyme Score Source PMID
Y713 Phosphorylation P07332 (FES) HPRD 8663427
Y811 Phosphorylation P07332 (FES) HPRD 8663427


P07332 (FES) as PTM Enzyme



Substrate Site Score Source PMID
P07332-1 (FES) Y713 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 8334128, 8955135, 7687763, ...8663427, 15485904, 18775312
P07332 (FES) Y811 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7687763, 8663427
P11274 (BCR) Y177 HPRD   neXtProt   phospho.ELM   Signor 10405761, 9178913, 9407116, ...8955135, 15302586, 12522270, 16497976
P11274 (BCR) Y246 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16497976, 8955135
P11274-2 (BCR) Y276 HPRD   phospho.ELM 8955135
P11274 (BCR) Y279 HPRD   phospho.ELM   Signor 8955135
P11274 (BCR) Y283 phospho.ELM   Signor 8955135
P16284 (PECAM1) Y690 Signor 12972546
P16284 (PECAM1) Y713 Signor 12972546
P46459 (NSF) Y83 PhosphoSitePlus 15322554


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y998 P07332 (FES) unknown eFIP 16273093
Phosphorylation P07332 (FES) Y713 P07332 (FES) unknown eFIP 7687763
Phosphorylation P07332 (FES) Y713 P15311 (EZR) unknown eFIP 18046454
Phosphorylation P07332 (FES) Y713 unknown eFIP 18046454
Phosphorylation P15311 (EZR) Y478 P07332 (FES) unknown eFIP 18046454
Phosphorylation Q8IZP0 (ABI1) Y421 P07332 (FES) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S412 L412 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3963 / thyroid carcinoma [ icgc ]
Y461 C461 Biomuta DOID:263 / kidney cancer [ tcga ]
S477 F477 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]