iPTMnet Report P06240 Lck

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P06240 / LCK_MOUSE
Protein Name	Proto-oncogene tyrosine-protein kinase LCK
Gene Name	Name: Lck Synonyms:Lsk-t;
Organism	Mus musculus (Mouse)

PRO ID	PR:P06240 DAG View
PRO Name	proto-oncogene tyrosine-protein kinase LCK (mouse)
Definition	A tyrosine-protein kinase Lck that is encoded in the genome of mouse.
Short Label	mLCK
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P06240 (Lck) as Substrate

P06240

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	G2	Myristoylation		score2	UniProt	7980442
	S35	Phosphorylation		score2	PRO PhosphoSitePlus	21183079
	S42	Phosphorylation		score1	PhosphoSitePlus
	S59	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	8226850, 8258696, 8077654
	S164	Phosphorylation		score1	PhosphoSitePlus
	Y192	Phosphorylation		score4	PRO PhosphoSitePlus RLIMS-P UniProt	21183079, 7997241
	Y394	Phosphorylation	P06240 (Lck)	score4	PhosphoSitePlus RLIMS-P	7997241, 22523384, 11294838, ...33684096, 2118992, 9658584, 33888137, 18981123, 2250907, 1311128, 8756658, 9973453
	T395	Phosphorylation		score1	PhosphoSitePlus
	Y505	Phosphorylation	P41241 (Csk) , P06240 (Lck)	score4	PhosphoSitePlus RLIMS-P	7997241, 11847223, 7694287, ...22523384, 16446380, 33684096, 9658584, 25595912, 17277109, 2468122, 8413300, 8441403, 8756658, 9973453

P06240 (Lck) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P06240 (Lck)	Y394	score2	PhosphoSitePlus	1311128
	P06240 (Lck)	Y505	score2	PhosphoSitePlus	11847223
	P09793 (Ctla4)	Y201	score3	phospho.ELM PhosphoSitePlus	9973379
	P09793 (Ctla4)	Y218	score3	phospho.ELM PhosphoSitePlus	9973379
	P27870 (Vav1)	Y142	score2	phospho.ELM	10669745
	P27870 (Vav1)	Y160	score2	phospho.ELM	10669745
	P27870 (Vav1)	Y174	score2	phospho.ELM	10669745
	P28867 (Prkcd)	Y311	score2	phospho.ELM	11381116
	P29351 (Ptpn6)	Y536	score1	Signor	8114715
	P43404 (Zap70)	Y318	score1	Signor	10037717
	P63085 (Mapk1)	Y185	score2	PhosphoSitePlus	1311128
	Q03526 (Itk)	Y517	score2	PhosphoSitePlus	12842872
	Q08481 (Pecam1)	Y679	score3	phospho.ELM PhosphoSitePlus	9624175
	Q08481 (Pecam1)	Y702	score2	PhosphoSitePlus	9624175
	Q9EQR5 (Lime1)	Y242	score2	PhosphoSitePlus	14610044
	Q9EQR5 (Lime1)	Y261	score2	PhosphoSitePlus	14610044
	Q9ES52 (Inpp5d)	Y918	score2	PhosphoSitePlus	9099679
	Q9ES52 (Inpp5d)	Y1021	score2	PhosphoSitePlus	9099679

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049824 (mLCK/Phos:2)	pS35		PRO	21183079
	PR:000049825 (mLCK/Phos:3)	pY192		PRO	21183079