iPTMnet Report for P03372 (ESR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P03372 / ESR1_HUMAN
Protein Name Estrogen receptor
Gene Name Name: ESR1
Synonyms:ESR,NR3A1;
Organism Homo sapiens (Human)

PRO ID PR:P03372
DAG View
PRO Name estrogen receptor (human)
Definition An estrogen receptor that is encoded in the genome of human.
Short Label hESR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P03372 (ESR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation RLIMS-P 27458161
T7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
S46 Phosphorylation phospho.ELM   PhosphoSitePlus 20043841
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 20043841
Y52 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20101225
Y52 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 20101225
S102 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18984578, 16076840
S102 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 16076840
S104 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11108261, 16076840, 10949034, ...20043841, 8308015, 17615152, 18372406, 25531331, 26522726, 16741565, 12118371, 18984578, 10428798
S104 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 18372406, 10428798, 16741565
S104 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 17615152, 18372406
S104 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 12118371, 18372406, 17615152
S104 Phosphorylation P31749 (AKT1) Signor 11108261
S104 Phosphorylation P42345 (MTOR) PhosphoSitePlus 26522726
S104 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 18372406, 16076840
S104 Phosphorylation Q00526 (CDK3) PhosphoSitePlus 25531331
S106 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26522726, 16076840, 10949034, ...20043841, 8308015, 17615152, 18372406, 25531331, 16741565, 12118371, 18984578, 10428798, 11108261
S106 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 10428798
S106 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 17615152, 18372406
S106 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 17615152, 18372406, 12118371
S106 Phosphorylation P31749 (AKT1) Signor 11108261
S106 Phosphorylation P42345 (MTOR) PhosphoSitePlus 26522726
S106 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 18372406, 16076840
S106 Phosphorylation Q00526 (CDK3) PhosphoSitePlus 25531331
S118 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 7491495, 14764652, 25728338, ...15461668, 16155796, 24508513, 17092701, 18984578, 9637719, 12118371, 23946788, 20093341, 26480297, 35654737, 18941890, 20219974, 12466266, 22399296, 19377875, 15788640, 23542176, 30034315, 18372406, 27641443, 17068199, 23609470, 33861751, 18550720, 7476978, 17936617, 15879307, 21071990, 24107627, 28498246, 15059947, 20689759, 12093745, 27689466, 29373839, 18853184, 36036613, 22284681, 20056081, 24631339, 29702197, 21356307, 20103631, 17158758, 15355923, 22549111, 16223974, 24586459, 17609434, 14977836, 21509526, 15919818, 16455819, 16168121, 11108261, 28847747, 17108142, 11083859, 16261397, 17187784, 20043841, 24825747, 16741565, 21505052, 18045953, 9699862, 19326083, 15528270, 22562654, 28423697, 15808510, 18350142, 21328450, 16538538, 12775708, 32105160, 16954434, 23094148, 17615152, 25531331, 21104395, 23265704, 16113101, 10428798, 7838153, 16076840, 10949034, 9528769, 17047081, 28522562, 28137613, 26468985, 23390529
S118 Phosphorylation O15111 (CHUK) PhosphoSitePlus 15808510
S118 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 18372406, 10428798
S118 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 17615152, 18372406, 15059947, ...7491495, 12466266
S118 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15059947, 7491495, 12093745, ...9528769, 17615152, 18372406, 12118371, 15919818, 12466266
S118 Phosphorylation P31749 (AKT1) Signor 11108261
S118 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+   Signor 17609434, 16076840
S118 Phosphorylation P50613 (CDK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12118371, 10949034, 15461668
S118 Phosphorylation P51948 (MNAT1) Signor 10949034
S118 Phosphorylation Q00526 (CDK3) PhosphoSitePlus 25531331
S118 Phosphorylation Q13888 (GTF2H2) Signor 10949034
S118 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 15879307
S154 Phosphorylation phospho.ELM   PhosphoSitePlus 18984578
S167 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24878609, 21292829, 19112174, ...16455819, 16113102, 16168121, 11108261, 35588983, 17908967, 21104395, 17092701, 18984578, 17187784, 11432835, 18550720, 11507039, 9337862, 24166501, 26186972, 21071990, 29707142, 23946788, 16741565, 26522726, 7838153, 20093341, 33861751, 9528769, 11139588, 23816933, 23390529, 18941890, 20056081, 24631339, 15528270, 28498246, 17158758, 17505062, 19925796, 22549111, 32105160, 18350142, 21509526, 30034315, 19940156, 29128895
S167 Phosphorylation O14965 (AURKA) PhosphoSitePlus 24166501
S167 Phosphorylation P23443 (RPS6KB1) neXtProt   PhosphoSitePlus   Signor 19925796, 7838153, 19112174
S167 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 11108261, 11139588, 16113102
S167 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus 11507039
S167 Phosphorylation P51812 (RPS6KA3) neXtProt   PhosphoSitePlus   Signor 19925796, 19112174, 11432835
S167 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 7838153, 9337862
S167 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus   Signor 19940156
S167 Phosphorylation Q15418 (RPS6KA1) neXtProt   PhosphoSitePlus   Signor 7838153, 19925796, 9528769
K171 Acetylation PhosphoSitePlus
K171 Methylation PhosphoSitePlus
K171 Sumoylation PhosphoSitePlus
K180 Methylation PhosphoSitePlus
K180 Sumoylation PhosphoSitePlus
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18984578, 22266331
Y219 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20101225
Y219 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 20101225
S236 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17513601, 18984578, 22266331, ...12475718, 16741565, 9891036
S236 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 16741565, 9891036
K244 Acetylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
R260 Methylation PhosphoSitePlus   UniProt 24498420, 18657504
R263 Methylation PhosphoSitePlus
K266 Acetylation PhosphoSitePlus
K266 Methylation PhosphoSitePlus
K266 Sumoylation PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
K268 Sumoylation PhosphoSitePlus
R277 Methylation PhosphoSitePlus
S282 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 20043841
S282 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 20043841
S294 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18984578, 20043841, 23390529, ...22669764, 22431515
S294 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 23390529
S294 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22431515
K299 Acetylation PhosphoSitePlus
K299 Sumoylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
K302 Methylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S305 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22319200, 24449872, 18755239, ...17068199, 16778166, 19205871, 12374744, 16452229, 24166501, 26554417, 16741565, 25447917, 20179234, 15178330, 17513601, 20093341, 34896436, 18521086, 22669764, 26272591, 17604944, 20213082, 20101208, 22907427, 32105160, 17627277, 28306507, 15604293, 15193262, 29128895, 21447808
S305 Phosphorylation O14965 (AURKA) PhosphoSitePlus 24166501
S305 Phosphorylation O96013 (PAK4) PhosphoSitePlus 26554417
S305 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 26272591, 15193262, 17627277, ...15604293, 16741565
S305 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 20101208
S305 Phosphorylation Q13153 (PAK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12374744
S305 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 24449872
T311 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22825349, 12138194, 32105160, ...16741565
T311 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12138194, 16741565
S341 Phosphorylation PhosphoSitePlus
K401 Methylation PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
K472 Sumoylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 35181438, 27472465, 7539106, ...9500442, 22930062, 21761367, 14963108, 8530431, 12475718, 10571988, 11032808, 16741565, 25386784, 22865929, 7543683
Y537 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus   Signor 7539106, 10571988, 9500442
Y537 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 7539106, 16741565, 9500442
T553 O-Glycosylation GlyGen 8999954, 30379171, 33731348
S554 O-Glycosylation GlyGen 8999954, 30379171, 33731348
S554 Phosphorylation phospho.ELM   PhosphoSitePlus 18984578
S559 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 20043841, 18984578
S559 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 20043841
S576 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y52 Phosphorylation PRO 20101225
Y52 Phosphorylation PR:P00519 (hABL1) PRO 20101225
S102 Phosphorylation HPRD 10949034
S102 Phosphorylation P51948 (MNAT1) HPRD 10949034
S104 Phosphorylation HPRD 8308015, 10949034
S104 Phosphorylation P51948 (MNAT1) HPRD 8308015, 10949034
S106 Phosphorylation HPRD 8308015, 10949034
S106 Phosphorylation P51948 (MNAT1) HPRD 8308015, 10949034
S118 Phosphorylation HPRD   PRO 12093745, 9528769, 18941890, ...15461668, 17615152, 10409727
S118 Phosphorylation P28482 (MAPK1) HPRD 12093745, 10409727, 9528769
S118 Phosphorylation P50613 (CDK7) HPRD 15461668
S118 Phosphorylation PR:000000019 (mitogen-activated protein kinase) PRO 17615152
S118 Phosphorylation Q15418 (RPS6KA1) HPRD 12093745, 9528769
S167 Phosphorylation HPRD   PRO 11432835, 18941890, 9528769, ...11139588, 19940156, 11507039
S167 Phosphorylation P31749 (AKT1) HPRD 11139588
S167 Phosphorylation P31751 (AKT2) HPRD 11139588, 11432835, 11507039, ...9528769
S167 Phosphorylation P51812 (RPS6KA3) HPRD 11139588, 11432835, 11507039, ...9528769
S167 Phosphorylation PR:Q14164 (hIKBKE) PRO 19940156
S167 Phosphorylation Q15418 (RPS6KA1) HPRD 11139588, 11432835, 11507039, ...9528769
Y219 Phosphorylation PRO 20101225
Y219 Phosphorylation PR:P00519 (hABL1) PRO 20101225
K266 Acetylation PRO 16497729
K266 Acetylation PR:000007102 (EP300) PRO 16497729
K268 Acetylation PRO 16497729
K268 Acetylation PR:000007102 (EP300) PRO 16497729
S305 Phosphorylation HPRD 12374744
S305 Phosphorylation Q13153 (PAK1) HPRD 12374744
T311 Phosphorylation HPRD   PRO 12138194
T311 Phosphorylation PR:Q16539 (hMAPK14) PRO 12138194
T311 Phosphorylation Q16539 (MAPK14) HPRD 12138194
Y537 Phosphorylation HPRD 7539106
Y537 Phosphorylation P06239 (LCK) HPRD 7539106
Y537 Phosphorylation P12931 (SRC) HPRD 7539106


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027724 (hESR1/iso:1/Phos:1) pS167 PR:Q14164 (hIKBKE) PRO 19940156
PR:000027726 (hESR1/iso:1/Phos:2) pY52,pY219 PR:P00519 (hABL1) PRO 20101225
PR:000027754 (hESR1/iso:1/Phos:3) pS118 PR:000000019 (mitogen-activated protein kinase) PRO 17615152
PR:000027756 (hESR1/iso:1/Ac:1) acK266,acK268 PR:000007102 (EP300) PRO 16497729
PR:000027776 (hESR1/iso:1/Phos:4) pT311 PR:Q16539 (hMAPK14) PRO 12138194
PR:000027778 (hESR1/iso:1/Phos:5) pS118,pS167 PRO 18941890


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03135 (CAV1) Y14 P03372 (ESR1) inhibited_association eFIP 20610538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 A4 Biomuta DOID:1324 / lung cancer [ cosmic ]
S10 C10 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K32 Q32 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S47 T47 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y52 H52 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S102 N102 Biomuta DOID:3571 / liver cancer [ cosmic ]
S106 G106 Biomuta DOID:1324 / lung cancer [ cosmic ]
S154 L154 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:1612 / breast cancer [ icgc ]
K171 M171 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K244 Q244 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K252 N252 Biomuta DOID:1612 / breast cancer [ cosmic ]
R260 K260 Biomuta DOID:1319 / brain cancer [ cosmic ]
R263 S263 Biomuta DOID:363 / uterine cancer [ cosmic ]
R263 I263 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R263 K263 Biomuta DOID:4159 / skin cancer [ cosmic ]
K268 N268 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K268 Q268 Biomuta DOID:1324 / lung cancer [ cosmic ]
R277 S277 Biomuta [ cosmic ]
R277 K277 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S282 C282 Biomuta DOID:1612 / breast cancer [ cosmic ]
S294 R294 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K299 R299 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ]
K302 T302 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K303 R303 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T311 M311 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S341 L341 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K401 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y537 C537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y537 S537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
Y537 H537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y537 D537 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y537 N537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S576 L576 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S578 Y578 Biomuta DOID:4159 / skin cancer [ cosmic ]
T594 M594 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]