Protein Information

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UniProt AC / UniProt ID P03372 / ESR1_HUMAN
Protein Name Estrogen receptor
Gene Name Name: ESR1
Synonyms:ESR,NR3A1;
Organism Homo sapiens (Human)

PRO ID PR:P03372
DAG View
PRO Name estrogen receptor (human)
Definition An estrogen receptor that is encoded in the genome of human.
Short Label hESR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P03372 (ESR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation RLIMS-P 27458161
T7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
S46 Phosphorylation phospho.ELM   PhosphoSitePlus 20043841
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 20043841
Y52 Phosphorylation P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20101225
S102 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18984578, 16076840
S104 Phosphorylation P49841 (GSK3B) , P27361 (MAPK3) , P28482 (MAPK1) , P31749 (AKT1) , P24941 (CDK2) , Q00526 (CDK3) , P42345 (MTOR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11108261, 16076840, 10949034, ...20043841, 8308015, 17615152, 18372406, 25531331, 26522726, 16741565, 12118371, 18984578, 10428798
S106 Phosphorylation P24941 (CDK2) , Q00526 (CDK3) , P49841 (GSK3B) , P28482 (MAPK1) , P27361 (MAPK3) , P42345 (MTOR) , P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26522726, 16076840, 10949034, ...20043841, 8308015, 17615152, 18372406, 25531331, 16741565, 12118371, 18984578, 10428798, 11108261
S118 Phosphorylation P24941 (CDK2) , P27361 (MAPK3) , P49841 (GSK3B) , P31749 (AKT1) , O15111 (CHUK) , Q16539 (MAPK14) , P50613 (CDK7) , Q13888 (GTF2H2) , P51948 (MNAT1) , Q00526 (CDK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 7491495, 14764652, 25728338, ...15461668, 16155796, 24508513, 17092701, 18984578, 9637719, 12118371, 23946788, 26480297, 18941890, 22733972, 20219974, 12466266, 22399296, 18436523, 19377875, 10428798, 23542176, 30034315, 18372406, 27641443, 17068199, 23609470, 33861751, 18550720, 7476978, 17936617, 15879307, 21071990, 24107627, 28498246, 16076840, 15059947, 20689759, 12093745, 29373839, 30978702, 18853184, 22284681, 20056081, 24631339, 29702197, 21356307, 20103631, 17158758, 20531297, 15355923, 22549111, 16223974, 23094148, 17609434, 14977836, 21509526, 15919818, 16455819, 16168121, 11108261, 28847747, 17108142, 16261397, 17187784, 20043841, 24825747, 16741565, 21505052, 18045953, 9699862, 30121621, 19326083, 15528270, 33024087, 22562654, 28423697, 15808510, 18350142, 21328450, 30455249, 16538538, 12775708, 32105160, 16954434, 24586459, 17615152, 25531331, 21104395, 31945389, 23265704, 31867329, 16113101, 15788640, 7838153, 20093341, 10949034, 9528769, 17047081, 28522562, 28137613, 27689466, 26468985, 23390529
S154 Phosphorylation phospho.ELM   PhosphoSitePlus 18984578
S167 Phosphorylation P31751 (AKT2) , O14965 (AURKA) , P68400 (CSNK2A1) , P51812 (RPS6KA3) , Q14164 (IKBKE) , P23443 (RPS6KB1) , P31749 (AKT1) , Q15418 (RPS6KA1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24878609, 21292829, 19112174, ...16455819, 16113102, 16168121, 11108261, 17908967, 28498246, 21104395, 17092701, 18984578, 17187784, 11432835, 18550720, 11507039, 9337862, 24166501, 26186972, 21071990, 29707142, 23946788, 16741565, 26522726, 7838153, 20093341, 33861751, 9528769, 11139588, 23816933, 23390529, 18941890, 20056081, 22733972, 24631339, 15528270, 33024087, 17158758, 20531297, 17505062, 19925796, 22549111, 32105160, 18350142, 21509526, 30034315, 19940156, 29128895
K171 Acetylation PhosphoSitePlus
K171 Methylation PhosphoSitePlus
K171 Sumoylation PhosphoSitePlus
K180 Methylation PhosphoSitePlus
K180 Sumoylation PhosphoSitePlus
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18984578, 22266331
Y219 Phosphorylation P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20101225
S236 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17513601, 18984578, 22266331, ...12475718, 16741565, 9891036
K244 Acetylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
R260 Methylation PhosphoSitePlus   UniProt 24498420, 18657504
K266 Acetylation PhosphoSitePlus
K266 Methylation PhosphoSitePlus
K266 Sumoylation PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
K268 Sumoylation PhosphoSitePlus
R277 Methylation PhosphoSitePlus
S282 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20043841
S294 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18984578, 20043841, 23390529, ...22669764, 22431515
K299 Acetylation PhosphoSitePlus
K299 Sumoylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
K302 Methylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S305 Phosphorylation Q13153 (PAK1) , P31749 (AKT1) , P17612 (PRKACA) , O14965 (AURKA) , Q9UHD2 (TBK1) , O96013 (PAK4) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22319200, 24449872, 18755239, ...17068199, 16778166, 19205871, 12374744, 16452229, 24166501, 26554417, 16741565, 25447917, 20179234, 15178330, 17513601, 20093341, 18521086, 22669764, 26272591, 30659843, 17604944, 20213082, 20101208, 22907427, 32105160, 17627277, 28306507, 15604293, 15193262, 29128895, 21447808
T311 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22825349, 12138194, 32105160, ...16741565
S341 Phosphorylation PhosphoSitePlus
K401 Methylation PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
K472 Sumoylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation P06239 (LCK) , P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9500442, 27472465, 7539106, ...22930062, 21761367, 14963108, 8530431, 12475718, 10571988, 11032808, 16741565, 25386784, 22865929, 7543683
S554 Phosphorylation phospho.ELM   PhosphoSitePlus 18984578
S559 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20043841, 18984578
S576 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y52 Phosphorylation PR:P00519 (hABL1) PRO 20101225
S102 Phosphorylation P51948 (MNAT1) HPRD 10949034
S104 Phosphorylation P51948 (MNAT1) HPRD 8308015, 10949034
S106 Phosphorylation P51948 (MNAT1) HPRD 8308015, 10949034
S118 Phosphorylation P28482 (MAPK1) , PR:000000019 (mitogen-activated protein kinase) , Q15418 (RPS6KA1) , P50613 (CDK7) HPRD   PRO 12093745, 9528769, 18941890, ...15461668, 17615152, 10409727
S167 Phosphorylation P31749 (AKT1) , P31751 (AKT2) , P51812 (RPS6KA3) , Q15418 (RPS6KA1) , PR:Q14164 (hIKBKE) HPRD   PRO 11432835, 18941890, 9528769, ...11139588, 19940156, 11507039
Y219 Phosphorylation PR:P00519 (hABL1) PRO 20101225
K266 Acetylation PR:000007102 (EP300) PRO 16497729
K268 Acetylation PR:000007102 (EP300) PRO 16497729
S305 Phosphorylation Q13153 (PAK1) HPRD 12374744
T311 Phosphorylation PR:Q16539 (hMAPK14) , Q16539 (MAPK14) HPRD   PRO 12138194
Y537 Phosphorylation P06239 (LCK) , P12931 (SRC) HPRD 7539106


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027724 (hESR1/iso:1/Phos:1) pS167 PR:Q14164 (hIKBKE) PRO 19940156
PR:000027726 (hESR1/iso:1/Phos:2) pY52,pY219 PR:P00519 (hABL1) PRO 20101225
PR:000027754 (hESR1/iso:1/Phos:3) pS118 PR:000000019 (mitogen-activated protein kinase) PRO 17615152
PR:000027756 (hESR1/iso:1/Ac:1) acK266,acK268 PR:000007102 (EP300) PRO 16497729
PR:000027776 (hESR1/iso:1/Phos:4) pT311 PR:Q16539 (hMAPK14) PRO 12138194
PR:000027778 (hESR1/iso:1/Phos:5) pS118,pS167 PRO 18941890


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P03372 (ESR1) Y537 P00523 (SRC) unknown eFIP 11032808
Phosphorylation P03372 (ESR1) Y537 P12931 (SRC) unknown eFIP 14963108
Phosphorylation Q03135 (CAV1) Y14 P03372 (ESR1) inhibited_association eFIP 20610538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 C10 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S47 T47 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y52 H52 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S102 N102 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S154 L154 Biomuta DOID:1612 / breast cancer [ icgc ]
K171 M171 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K252 N252 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K268 N268 Biomuta DOID:1324 / lung cancer [ tcga ]
K268 Q268 Biomuta DOID:1324 / lung cancer [ cosmic ]
K302 T302 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K303 R303 Biomuta DOID:1612 / breast cancer [ clinvar, cosmic ]
T311 M311 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S341 L341 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K401 R401 Biomuta DOID:5041 / esophageal cancer [ icgc ]
Y537 N537 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1612 / breast cancer [ civic, cosmic ]
Y537 C537 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ civic, cosmic, icgc ]
Y537 S537 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1612 / breast cancer [ civic, cosmic ]
Y537 H537 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ tcga ]
S576 L576 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ cosmic ]
T594 M594 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]