iPTMnet Report for P01111 (NRAS)
Protein Information
UniProt AC / UniProt ID | P01111 / RASN_HUMAN |
Protein Name | GTPase NRas precursor |
Gene Name | Name: NRAS Synonyms:HRAS1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P01111 |
PRO Name | GTPase NRas (human) |
Definition | A GTPase NRas that is encoded in the genome of human. |
Short Label | hNRAS |
Category | organism-gene |
P01111 (NRAS) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y32 | Phosphorylation | score2 | PhosphoSitePlus | 25157176 | ||
Y32 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 25157176 | |
T35 | O-Glycosylation | score2 | UniProt | 19744486 | ||
S39 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y40 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y64 | Phosphorylation | score1 | PhosphoSitePlus | |||
C80 | Methylation | score1 | IEDB | 31844290 | ||
C80 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K88 | Methylation | score1 | PhosphoSitePlus | |||
S89 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 30712867 | ||
S89 | Phosphorylation | P49842 (STK19) | score1 | Signor | 30712867 | |
K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
C118 | S-Nitrosylation | score2 | dbSNO | 22178444, 18641128 | ||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
K135 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y137 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25999467 | ||
K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
T148 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y157 | Phosphorylation | score1 | PhosphoSitePlus | |||
T158 | Phosphorylation | score1 | PhosphoSitePlus | |||
K170 | Ubiquitination | score2 | UniProt | 30442762 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y32 | * | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
Y40 | D40 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y40 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y64 | C64 | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
Y64 | N64 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
Y64 | D64 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K117 | R117 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K135 | N135 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
T148 | I148 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T148 | S148 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |