Protein Information

Cytoscape View

UniProt AC / UniProt ID P01111 / RASN_HUMAN
Protein Name GTPase NRas precursor
Gene Name Name: NRAS
Organism Homo sapiens (Human)

PRO ID PR:P01111
DAG View
PRO Name GTPase NRas (human)
Definition A GTPase NRas that is encoded in the genome of human.
Short Label hNRAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P01111 (NRAS) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y32 Phosphorylation P12931 (SRC) PhosphoSitePlus 25157176
S39 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
C80 S-Nitrosylation dbSNO 26338901
K88 Methylation PhosphoSitePlus
S89 Phosphorylation UniProt 30712867
K117 Ubiquitination PhosphoSitePlus
C118 S-Nitrosylation dbSNO 22178444, 18641128
K128 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
K170 Ubiquitination UniProt 30442762

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y32 * Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
Y40 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T148 N148 Biomuta DOID:3571 / liver cancer [ icgc ]