iPTMnet Report for P01106 (MYC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01106 / MYC_HUMAN
Protein Name Myc proto-oncogene protein
Gene Name Name: MYC
Synonyms:BHLHE39;
Organism Homo sapiens (Human)

PRO ID PR:P01106
DAG View
PRO Name Myc proto-oncogene protein (human)
Definition A c-myc protein that is encoded in the genome of human.
Short Label hMYC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01106 (MYC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S21 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T23 Phosphorylation PhosphoSitePlus   UniProt 9315742
Y27 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
K66 Sumoylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
T73 O-Glycosylation GlyGen   PhosphoSitePlus 7642555
T73 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...17558397, 8386367, 18669648, 15103331
S77 Phosphorylation PhosphoSitePlus   UniProt 22307329, 21406692, 23186163, ...20713526, 17558397, 25438055, 18669648, 8386367, 19966300, 25803737, 15103331
S79 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
Y89 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
K158 Acetylation PhosphoSitePlus   UniProt 16126174
K163 Acetylation PhosphoSitePlus   UniProt 19608861
K163 Sumoylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus   UniProt 16126174
K172 Sumoylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus   UniProt 20068231
S217 Phosphorylation RLIMS-P 26284497
S249 Phosphorylation PhosphoSitePlus 2663470
S249 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 2663470
T259 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus   UniProt 16126174
S292 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus   UniProt 23186163
K313 Ubiquitination PhosphoSitePlus
R314 Methylation PhosphoSitePlus
S329 Phosphorylation neXtProt   RLIMS-P 31501481, 24830942, 18438430
S329 Phosphorylation P11309 (PIM1) neXtProt 18438430
S329 Phosphorylation Q9P1W9 (PIM2) neXtProt 18438430
K332 Acetylation PhosphoSitePlus   UniProt 16126174
K332 Sumoylation PhosphoSitePlus
K338 Acetylation PhosphoSitePlus   UniProt 16126174
K338 Sumoylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K341 Sumoylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
T358 Phosphorylation neXtProt   PhosphoSitePlus 14749374
T358 Phosphorylation Q13177 (PAK2) neXtProt 14749374
S359 Phosphorylation PhosphoSitePlus
R361 Methylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
K370 Sumoylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
K386 Acetylation PhosphoSitePlus   UniProt 16126174
S388 Phosphorylation PhosphoSitePlus
K404 Sumoylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K407 Sumoylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K413 Sumoylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K427 Sumoylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K445 Sumoylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T58 O-Glycosylation PRO 7642555, 11904304
T58 Phosphorylation PRO 7623799, 19131971
S62 Phosphorylation PRO 7623799, 19131971, 12676581
S71 Phosphorylation PRO 12676581
K143 Acetylation PRO 16126174
K157 Acetylation PRO 16126174
K275 Acetylation PRO 16126174
K317 Acetylation PRO 16126174
K323 Acetylation PRO 16126174
K323 Ubiquitination PhosphoSitePlus
K371 Acetylation PRO 16126174
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 19664995, 20068231
T73 Phosphorylation HPRD 19651622, 2663470, 18669648, ...20068231
T73 Phosphorylation P19784 (CSNK2A2) HPRD 19651622, 2663470, 18669648, ...20068231
T73 Phosphorylation P49841 (GSK3B) HPRD 19651622, 2663470, 18669648, ...20068231
T73 Phosphorylation P68400 (CSNK2A1) HPRD 19651622, 2663470, 18669648, ...20068231
S77 Phosphorylation HPRD 10551811, 19651622, 18669648, ...1748630, 20068231
S77 Phosphorylation P45983 (MAPK8) HPRD 10551811, 19651622, 18669648, ...1748630, 20068231
S79 Phosphorylation HPRD 19651622, 20068231
S86 Phosphorylation HPRD 10551811, 18767875, 18669648
S86 Phosphorylation P45983 (MAPK8) HPRD 10551811, 18767875, 18669648
S88 Phosphorylation HPRD 20068231
S176 Phosphorylation HPRD 20068231
S359 Phosphorylation HPRD 19413330
S363 Phosphorylation HPRD 19413330
T365 Phosphorylation HPRD 19413330


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048491 (hMYC/UbiqLys+) ub PRO
PR:000026033 (hMYC/iso:1/Ac:1) acK143,acK157,acK275,acK317,acK323,acK371 PRO 16126174
PR:000026041 (hMYC/iso:1/Phos:4) pT58 PRO 19131971
PR:000026054 (hMYC/iso:1/Phos:2) pT58,pS62 PRO 7623799
PR:000026055 (hMYC/iso:1/Phos:3) pS62,pS71 PRO 12676581
PR:000036448 (hMYC/iso:1/Phos:1) pS62 PRO 19131971


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10415 (BCL2) S70 P01106 (MYC) unknown eFIP 15210690
Phosphorylation Q92995 (USP13) Y708 P01106 (MYC) unknown eFIP 32453420
Phosphorylation Q9BWT1 (CDCA7) T163 P01106 (MYC) unknown eFIP 23166294


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036448 (hMYC/iso:1/Phos:1) Interaction PR:O15169-1 (hAXIN1/iso:1) PRO 19131971
PR:O15169-1 (hAXIN1/iso:1) Interaction PR:000036448 (hMYC/iso:1/Phos:1) PRO 19131971
PR:P01106-1 (hMYC/iso:1) Interaction PRO 12706874


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S217 N217 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S217 R217 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S217 T217 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S249 R249 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S303 T303 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S329 F329 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K341 R341 Biomuta DOID:363 / uterine cancer [ cosmic ]
S344 N344 Biomuta DOID:4159 / skin cancer [ cosmic ]
T358 S358 Biomuta DOID:10534 / stomach cancer [ cosmic ]