Protein Information

Cytoscape View


UniProt AC / UniProt ID P01106 / MYC_HUMAN
Protein Name Myc proto-oncogene protein
Gene Name Name: MYC
Synonyms:BHLHE39;
Organism Homo sapiens (Human)

PRO ID PR:P01106
DAG View
PRO Name Myc proto-oncogene protein (human)
Definition A c-myc protein that is encoded in the genome of human.
Short Label hMYC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01106 (MYC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S6 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 20068231, 23084634
T8 Phosphorylation P04049 (RAF1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 9315742
Y12 Phosphorylation PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation P00519 (ABL1) PhosphoSitePlus 23318434
K51 Sumoylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K52 Sumoylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T58 O-Glycosylation PhosphoSitePlus
T58 Phosphorylation P49841 (GSK3B) , P28482 (MAPK1) , P49840 (GSK3A) , P53779 (MAPK10) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16247449, 20974860, 11679086, ...29258530, 8108117, 21618595, 27840026, 21406692, 29382851, 24265759, 15048125, 15103331, 18426604, 21808024, 10713166, 17558397, 26096843, 27253416, 31068129, 17081983, 30514931, 17634226, 22457068, 22525269, 30003124, 30037819, 30655559, 15150404, 10224279, 16023596, 19164469, 24901999, 23950719, 26771234, 16855632, 23318434, 29763736, 25499223, 8386367, 10551811, 31015523, 29445227, 21266350, 24662831, 20046830, 22389469, 30262141, 30221473, 22893788, 23186163, 26049366, 25944903, 12821782, 27991931, 16263084, 12748197, 25647305, 10706881, 18669648, 17310999, 29221209, 26136212, 29507657, 19620247, 18408012, 27401245, 26675138, 23755096, 19779850, 14563837, 21575199, 10825194, 16210249, 27795300, 16452238, 21772844, 25333250, 11904304, 27684546, 26317998, 27009366, 11018017, 15467756, 10866684, 7642555, 26701207, 17192266, 27542271, 30158517
S62 Phosphorylation Q13627 (DYRK1A) , P45984 (MAPK9) , Q00535 (CDK5) , P28482 (MAPK1) , P45983 (MAPK8) , Q92630 (DYRK2) , P53779 (MAPK10) , P42345 (MTOR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 19966300, 27705940, 11679086, ...1651323, 24607848, 29258530, 8108117, 21266350, 31311847, 21406692, 25944903, 21659604, 15103331, 18426604, 21808024, 30349298, 29383095, 27253416, 31068129, 17081983, 25893300, 17634226, 22457068, 28620180, 29472550, 22525269, 21575199, 10022608, 22826122, 30478051, 15048125, 29190822, 16537924, 10224279, 30526305, 16483932, 23716601, 24901999, 23950719, 26771234, 16855632, 29383130, 23318434, 29763736, 28967903, 15992821, 28830912, 8386367, 8788033, 10551811, 24236059, 31015523, 19734450, 29445227, 31243099, 9050996, 17558397, 24927563, 30262141, 20101459, 23186163, 26049366, 22015557, 12821782, 26918941, 27991931, 25304236, 20713526, 12748197, 20140016, 11243879, 19623651, 18669648, 26136212, 29507657, 19620247, 18408012, 28410006, 22307329, 20445224, 26675138, 18220336, 23755096, 19779850, 30366908, 30423298, 1332967, 26701207, 21772844, 27167001, 11904304, 27684546, 27009366, 11018017, 1748630, 22653959, 17192266, 30158517
S64 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S71 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P45983 (MAPK8) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 11243879, 10551811, ...18669648, 30158517
Y74 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P 23318434
T78 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus   RLIMS-P 30158517
K143 Acetylation PhosphoSitePlus   UniProt 16126174
K148 Acetylation PhosphoSitePlus   UniProt 19608861
K148 Sumoylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus   RLIMS-P 30158517
K157 Acetylation PhosphoSitePlus   UniProt 16126174
K157 Sumoylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S159 Phosphorylation RLIMS-P 30158517
S161 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 20068231, 30158517
T244 Phosphorylation RLIMS-P 24998853
S249 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 2663470
S250 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 2663470
S252 Phosphorylation P68400 (CSNK2A1) , P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P+ 2663470, 22025562
K275 Acetylation PhosphoSitePlus   UniProt 16126174
S277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus   UniProt 23186163
K298 Ubiquitination PhosphoSitePlus
S314 Phosphorylation RLIMS-P 30158517
T315 Phosphorylation RLIMS-P 30158517
K317 Acetylation PhosphoSitePlus   UniProt 16126174
K317 Sumoylation PhosphoSitePlus
K323 Acetylation PhosphoSitePlus   UniProt 16126174
K323 Sumoylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S329 Phosphorylation P11309 (PIM1) , Q9P1W9 (PIM2) neXtProt   PhosphoSitePlus 18438430
S337 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus   RLIMS-P 30158517
S347 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 2663470, 30158517
S348 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 2663470, 30158517
T350 Phosphorylation PhosphoSitePlus
K355 Sumoylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
T358 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P 20043278, 14749374
K371 Acetylation PhosphoSitePlus   UniProt 16126174
S373 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P 20043278, 14749374, 23550155
K389 Sumoylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K392 Sumoylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K398 Sumoylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
T400 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P 20043278, 14749374
S405 Phosphorylation PhosphoSitePlus
K412 Sumoylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K430 Sumoylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T58 O-Glycosylation PRO 7642555, 11904304
T58 Phosphorylation PRO 7623799, 19131971
S62 Phosphorylation PRO 7623799, 19131971, 12676581
S71 Phosphorylation PRO 12676581
K143 Acetylation PRO 16126174
K157 Acetylation PRO 16126174
K275 Acetylation PRO 16126174
K317 Acetylation PRO 16126174
K323 Acetylation PRO 16126174
K371 Acetylation PRO 16126174
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 19664995, 20068231
T73 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) , P49841 (GSK3B) HPRD 19651622, 2663470, 18669648, ...20068231
S77 Phosphorylation P45983 (MAPK8) HPRD 10551811, 19651622, 18669648, ...1748630, 20068231
S79 Phosphorylation HPRD 19651622, 20068231
S86 Phosphorylation P45983 (MAPK8) HPRD 10551811, 18767875, 18669648
S88 Phosphorylation HPRD 20068231
S176 Phosphorylation HPRD 20068231
S359 Phosphorylation HPRD 19413330
S363 Phosphorylation HPRD 19413330
T365 Phosphorylation HPRD 19413330


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048491 (hMYC/UbiqLys+) ub PRO
PR:000026033 (hMYC/iso:1/Ac:1) acK143,acK157,acK275,acK317,acK323,acK371 PRO 16126174
PR:000026041 (hMYC/iso:1/Phos:4) pT58 PRO 19131971
PR:000026054 (hMYC/iso:1/Phos:2) pT58,pS62 PRO 7623799
PR:000026055 (hMYC/iso:1/Phos:3) pS62,pS71 PRO 12676581
PR:000036448 (hMYC/iso:1/Phos:1) pS62 PRO 19131971


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01106 (MYC) T58 Q969H0 (FBXW7) unknown eFIP 15150404
Phosphorylation P01106 (MYC) T58 Q9UKT7 (FBXL3) unknown eFIP 30655559
Phosphorylation P01106 (MYC) T58 P68363 (TUBA1B) inhibited_association eFIP 10866684
Phosphorylation P10415 (BCL2) S70 P01106 (MYC) unknown eFIP 15210690
Phosphorylation P46527 (CDKN1B) T157 P01106 (MYC) inhibited_association eFIP 26701207


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036448 (hMYC/iso:1/Phos:1) Interaction PR:O15169-1 (hAXIN1/iso:1) PRO 19131971
PR:O15169-1 (hAXIN1/iso:1) Interaction PR:000036448 (hMYC/iso:1/Phos:1) PRO 19131971
PR:P01106-1 (hMYC/iso:1) Interaction PRO 12706874