iPTMnet Report for P01100 (FOS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01100 / FOS_HUMAN
Protein Name Protein c-Fos
Gene Name Name: FOS
Synonyms:G0S7;
Organism Homo sapiens (Human)

PRO ID PR:P01100
DAG View
PRO Name protein c-Fos (human)
Definition A protein c-Fos that is encoded in the genome of human.
Short Label hFOS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01100 (FOS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation PhosphoSitePlus   UniProt 17160021, 22105363
Y30 Phosphorylation PhosphoSitePlus   UniProt 17160021, 22105363
S32 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 17018293
S32 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus 17018293
S56 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
S57 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
S70 Phosphorylation RLIMS-P 18822310
S83 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
S84 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
S88 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
T90 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K176 Sumoylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T232 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8072547, 29422527, 7816602, ...30312728, 18822310, 23667255, 17018293
T232 Phosphorylation P27361 (MAPK3) phospho.ELM   Signor 7816602
T232 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7816602
T232 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus 17018293
S258 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K265 Sumoylation PhosphoSitePlus
S278 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
S278 Phosphorylation PhosphoSitePlus
S283 O-Glycosylation GlyGen 34725712, 15327282, 30515991, ...29351928
S308 Phosphorylation PhosphoSitePlus 19285436
S308 Phosphorylation O14920 (IKBKB) PhosphoSitePlus 19285436
T325 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12134156, 12972619, 29422527, ...21552553, 18822310, 23667255, 29535732
T325 Phosphorylation P27361 (MAPK3) phospho.ELM   Signor 12972619
T325 Phosphorylation P28482 (MAPK1) neXtProt   Signor 12134156, 12972619
T331 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12134156, 12972619, 29422527, ...18822310, 23667255
T331 Phosphorylation P27361 (MAPK3) phospho.ELM   Signor 12972619
T331 Phosphorylation P28482 (MAPK1) neXtProt   Signor 12134156, 12972619
S362 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 1545828, 9920881, 23400877, ...15719069, 7588633, 26725323, 8248197, 21552553, 11585927, 21219922, 22187936
S362 Phosphorylation O75676 (RPS6KA4) Signor 8248197, 22187936
S362 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   Signor 8248197, 11585927
S363 Phosphorylation PhosphoSitePlus
S374 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27486656, 12134156, 23400877, ...29422527, 26725323, 7588633, 8248197, 18822310, 23667255, 12972619, 21219922
S374 Phosphorylation P27361 (MAPK3) Signor 12972619
S374 Phosphorylation P28482 (MAPK1) neXtProt   Signor 12134156, 12972619
T376 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T114 Phosphorylation HPRD 20068231
T232 Phosphorylation HPRD 7816602
T232 Phosphorylation P28482 (MAPK1) HPRD 7816602
T325 Phosphorylation HPRD   PRO 12134156, 12972619
T325 Phosphorylation P28482 (MAPK1) HPRD 12972619
T331 Phosphorylation HPRD   PRO 12134156, 12972619
T331 Phosphorylation P28482 (MAPK1) HPRD 12972619
S362 Phosphorylation HPRD   PRO 1545828, 12134156, 20068231, ...8248197, 18452278
S362 Phosphorylation P17612 (PRKACA) HPRD 1545828, 8248197, 20068231, ...18452278
S362 Phosphorylation Q15418 (RPS6KA1) HPRD 1545828, 8248197, 20068231, ...18452278
S374 Phosphorylation HPRD   PRO 8248197, 12134156, 20068231, ...18452278
S374 Phosphorylation P28482 (MAPK1) HPRD 8248197, 20068231, 18452278


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047442 (hFOS/Phos:1) pT325,pT331,pS362,pS374 PRO
PR:000026843 (hFOS/iso:1/Phos:1) pT325,pT331,pS362,pS374 PRO 12134156


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01100 (FOS) S374 Q8NHM5 (KDM2B) decreased_association eFIP 26725323
Phosphorylation P05412 (JUN) S73 P01100 (FOS) increased_association eFIP 19860880


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S258 I258 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S363 N363 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]