Protein Information

Cytoscape View


UniProt AC / UniProt ID P01100 / FOS_HUMAN
Protein Name Proto-oncogene c-Fos
Gene Name Name: FOS
Synonyms:G0S7;
Organism Homo sapiens (Human)

PRO ID PR:P01100
DAG View
PRO Name proto-oncogene c-Fos (human)
Definition A proto-oncogene c-Fos that is encoded in the genome of human.
Short Label hFOS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01100 (FOS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 17160021, 22105363
Y30 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 17160021, 22105363
S32 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus   RLIMS-P 24184327, 17018293
S70 Phosphorylation RLIMS-P 18822310
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K176 Sumoylation PhosphoSitePlus
T232 Phosphorylation Q13164 (MAPK7) , P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18822310, 23667255, 17018293, ...7816602
K265 Sumoylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S308 Phosphorylation O14920 (IKBKB) PhosphoSitePlus 19285436
T325 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12134156, 12972619, 21552553, ...18822310, 23667255
T331 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12134156, 12972619, 18822310, ...23667255
S362 Phosphorylation O75676 (RPS6KA4) , P27361 (MAPK3) , Q15418 (RPS6KA1) , P28482 (MAPK1) , P51812 (RPS6KA3) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 1545828, 9920881, 23400877, ...15719069, 7588633, 26725323, 8248197, 21552553, 11585927, 21219922, 22187936
S363 Phosphorylation PhosphoSitePlus
S374 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27486656, 23400877, 12134156, ...7588633, 26725323, 8248197, 18822310, 23667255, 12972619, 21219922
T376 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T114 Phosphorylation HPRD 20068231
T232 Phosphorylation P28482 (MAPK1) HPRD 7816602
T325 Phosphorylation P28482 (MAPK1) HPRD   PRO 12134156, 12972619
T331 Phosphorylation P28482 (MAPK1) HPRD   PRO 12134156, 12972619
S362 Phosphorylation P17612 (PRKACA) , Q15418 (RPS6KA1) HPRD   PRO 1545828, 12134156, 20068231, ...8248197, 18452278
S374 Phosphorylation P28482 (MAPK1) HPRD   PRO 8248197, 12134156, 20068231, ...18452278


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047442 (hFOS/Phos:1) pT325,pT331,pS362,pS374 PRO
PR:000026843 (hFOS/iso:1/Phos:1) pT325,pT331,pS362,pS374 PRO 12134156


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01100 (FOS) S374 Q8NHM5 (KDM2B) decreased_association eFIP 26725323
Phosphorylation P05412 (JUN) S73 P01100 (FOS) increased_association eFIP 19860880
Phosphorylation P05412 (JUN) S63 P01100 (FOS) increased_association eFIP 19860880