iPTMnet Report P01023 A2M

Protein Information

UniProt AC / UniProt ID	P01023 / A2MG_HUMAN
Protein Name	Alpha-2-macroglobulin precursor
Gene Name	Name: A2M Synonyms:CPAMD5;ORFNames:FWP007;
Organism	Homo sapiens (Human)

PRO ID	PR:P01023 DAG View
PRO Name	alpha-2-macroglobulin (human)
Definition	An alpha-2-macroglobulin that is encoded in the genome of human.
Short Label	hA2M
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P01023 (A2M) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S26 N55 N70 N247 T346 N396 N410 Y497 C563 S575 T588 T654 T679 Y695 Y708 S710 T763 Y817 K820 K841 T861 N869 T885 T898 N991 Y1007 Y1012 Y1021 Y1025 K1147 K1162 K1164 K1168 S1387 T1395 N1424	PTM Type Select all Acetylation Methylation N-Glycosylation O-Glycosylation Phosphorylation Ubiquitination	Score Select all 1 2 3 4	Source Select all GlyGen HPRD IEDB PhosphoSitePlus UniProt	PMID
S26	O-Glycosylation	score1	GlyGen	30459171
N55	N-Glycosylation	score2	GlyGen UniProt	16335952, 23090970, 19139490, ...29741879, 34725484
N70	N-Glycosylation	score3	GlyGen UniProt	6203908
N247	N-Glycosylation	score4	GlyGen UniProt	16335952, 23090970, 29671580, ...29741879, 6203908
T346	Phosphorylation	score1	PhosphoSitePlus
N396	N-Glycosylation	score4	GlyGen UniProt	16335952, 23090970, 29671580, ...19159218, 6203908
N410	N-Glycosylation	score4	GlyGen UniProt	16335952, 23090970, 29671580, ...6203908
Y497	Phosphorylation	score1	PhosphoSitePlus
C563	Methylation	score1	IEDB	31844290
S575	O-Glycosylation	score1	GlyGen	30459171
T588	O-Glycosylation	score1	GlyGen	30459171
T654	O-Glycosylation	score1	GlyGen	30459171
T679	Phosphorylation	score2	HPRD PhosphoSitePlus	20068231
Y695	Phosphorylation	score1	PhosphoSitePlus
Y708	Phosphorylation	score1	PhosphoSitePlus
S710	Phosphorylation	score1	PhosphoSitePlus
T763	O-Glycosylation	score1	GlyGen	30459171
Y817	Phosphorylation	score1	PhosphoSitePlus
K820	Acetylation	score1	PhosphoSitePlus
K841	Ubiquitination	score1	IEDB	34433824
T861	Phosphorylation	score1	PhosphoSitePlus
N869	N-Glycosylation	score2	GlyGen IEDB UniProt	16335952, 34725484, 23090970, ...14760718, 24279413, 29741879, 29671580, 27550523
T885	O-Glycosylation	score1	GlyGen	30459171
T898	Phosphorylation	score1	PhosphoSitePlus
N991	N-Glycosylation	score4	GlyGen UniProt	16335952, 29741879, 12754519, ...19159218, 6203908
Y1007	Phosphorylation	score1	PhosphoSitePlus
Y1012	Phosphorylation	score1	PhosphoSitePlus
Y1021	Phosphorylation	score1	PhosphoSitePlus
Y1025	Phosphorylation	score1	PhosphoSitePlus
K1147	Acetylation	score1	PhosphoSitePlus
K1162	Acetylation	score1	PhosphoSitePlus
K1164	Acetylation	score1	PhosphoSitePlus
K1168	Acetylation	score1	PhosphoSitePlus
S1387	Phosphorylation	score1	PhosphoSitePlus
T1395	Phosphorylation	score1	PhosphoSitePlus
N1424	N-Glycosylation	score2	GlyGen UniProt	16335952, 34725484, 24530628, ...19159218, 23090970, 14760718, 29391424, 19139490, 24279413, 18514042, 29741879, 29671580

Search:

Site Select all By amino acid By position N247 N396 N410 N869 N1424	PTM Type Select all N-Glycosylation	Score Select all 1	Source Select all PRO	PMID
N247	N-Glycosylation	score1	PRO	29671580
N396	N-Glycosylation	score1	PRO	29671580
N410	N-Glycosylation	score1	PRO	29671580
N869	N-Glycosylation	score1	PRO	29671580
N1424	N-Glycosylation	score1	PRO	24279413, 29671580

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position N410 S575 Y695 Y817 T885 Y1025 K1162 S1387 T1395	Variant Select all * A885 C1025 C695 C817 K1395 P575 T410 Y1387	Source Select all Biomuta	Disease [Sample source] Select all DOID:11054 / urinary bladder cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3953 / adrenal gland cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
N410	T410	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S575	P575	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S575	*	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
Y695	C695	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y817	C817	Biomuta	DOID:3953 / adrenal gland cancer [ cosmic ]
T885	A885	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
Y1025	C1025	Biomuta	DOID:363 / uterine cancer [ cosmic ]
K1162	*	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S1387	Y1387	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T1395	K1395	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P01023 (A2M)

Protein Information

Interactive Sequence View

P01023 (A2M) as Substrate

PTM sites affected in variants